| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
RAB8A |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the Rab8 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Rab8 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P61006 |
| Purity: |
Antigen affinity |
| Description: |
It has been shown to interact with Optineurin and MAP4K2, Rab8 regulates cilia assembly by targeting and promoting fusion of vesicles near the ciliary membrane, The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane, The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids, This gene requires CEP290 for centrosome localization and that CEP290 regulates entry of Rab8 into the cilium during assembly of this organelle, Ras-related protein Rab8 is a protein that in humans is encoded by the RAB8A gene |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human Rab8A (KAKMDKKLEGNSPQ) was used as the immunogen for this Rab8 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Rab8 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
RAB8A |
| Short name: |
RAB8A Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member RAS oncogene family (Antibody to), RAB8A |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
MEL and RAB8, RAB8A and IDBG-35329 and ENSG00000167461 and 4218, RAB8A and IDBG-642338 and ENSBTAG00000038696 and 100125881, Rab8a and IDBG-167493 and ENSMUSG00000003037 and 17274, member RAS oncogene family, nuclei, protein kinase binding, this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000139 and this GO lgi membrane and cellular component this GO :0000278 and mitotic cell cycle and biological process this GO :0003924 and GTPase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005525 and GTP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005813 and centrosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005929 and cilium and cellular component this GO :0006184 and GTP catabolic process and biological process this GO :0006886 and intracellular protein transport and biological process this GO :0006904 and vesicle docking involved in exocytosis and biological process this GO :0006913 and nucleocytoplasmic transport and biological process this GO :0007165 and signal transduction and biological process this GO :0007264 and small GTPase mediated signal transduction and biological process this GO :0007409 and axonogenesis and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0015031 and protein transport and biological process this GO :0016020 and membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0017137 and Rab GTPase binding and molecular function this GO :0019003 and GDP binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030140 and trans- this GO lgi network transport vesicle and cellular component this GO :0030425 and dendrite and cellular component this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0030670 and pha this GO cytic vesicle membrane and cellular component this GO :0031513 and nonmotile primary cilium and cellular component this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0042384 and cilium assembly and biological process this GO :0043025 and neuronal cell body and cellular component this GO :0045335 and pha this GO cytic vesicle and cellular component this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048210 and this GO lgi vesicle fusion to target membrane and biological process this GO :0051223 and regulation of protein transport and biological process this GO :0055037 and recycling endosome and cellular component this GO :0055038 and recycling endosome membrane and cellular component this GO :0061024 and membrane organization and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0072659 and protein localization to plasma membrane and biological process, this GO :0003924 : GTPase activity, this GO :0003924 : GTPase activity and also this GO :0005515 : protein binding and also this GO :0005525 : GTP binding and also this GO :0017137 : Rab GTPase binding and also this GO :0019003 : GDP binding and also this GO :0019901 : protein kinase binding, this GO :0005515 : protein binding, this GO :0005525 : GTP binding, this GO :0017137 : Rab GTPase binding, this GO :0019003 : GDP binding, this GO :0019901 : protein kinase binding, RAB8A |
| Identity: |
7007 |
| Gene: |
RAB8A |
More about : RAB8A |
| Long gene name: |
RAB8A, member RAS oncogene family |
| Synonyms gene: |
MEL |
| Synonyms gene name: |
mel transforming oncogene (derived from cell line NK14) |
| Synonyms: |
RAB8 |
| Locus: |
19p13, 11 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
4218 |
| Pubmed identfication: |
1886711 8408203 |
| RefSeq identity: |
NM_005370 |
| Classification: |
RAB, member RAS oncogene GTPases |
| Havana BLAST/BLAT: |
OTTHUMG00000182238 |