| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ATP7B |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the ATP7B antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ATP7B antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P35670 |
| Purity: |
Antigen affinity |
| Description: |
ATP7B is mapped to 13q14, ATP7B redistributes to a vesicular compartment near the biliary canalicular membranes for elimination of excess copper into bile, Cu++ transporting, The protein functions as a monomer, This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, When copper levels are in excess, a hinge domain, a phosphorylation site, also called ATP7B, an ATPase consensus sequence, and at least two putative copper-binding sites, and it is transported along liver cell microtubules via interaction with the p62 Dynactin subunit, beta polypeptide, exporting copper out of the cells, is an ATPase that transports copper, 3, ATPase |
| Immunogen: |
An amino acid sequence from the C-terminus of human ATP7B (DKWSLLLNGRDEEQYI) was used as the immunogen for this ATP7B antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ATP7B antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ATP7B |
| Short name: |
ATP7B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ATP7B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
870 |
| Gene: |
ATP7B |
More about : ATP7B |
| Long gene name: |
ATPase copper transporting beta |
| Synonyms gene: |
WND |
| Synonyms gene name: |
ATPase, Cu++ transporting, Cu++ transporting, beta polypeptide , beta polypeptide (Wilson disease) ATPase |
| Synonyms name: |
Wilson disease copper pump 2 copper-transporting ATPase 2 |
| Locus: |
13q14, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
U11700 |
| Entrez gene record: |
540 |
| Pubmed identfication: |
8298641 8298639 |
| RefSeq identity: |
NM_000053 |
| Classification: |
ATPase copper transporting |
| Havana BLAST/BLAT: |
OTTHUMG00000017406 |
| Locus Specific Databases: |
Wilson Disease Mutation Database UMD Locus Specific Databases |