| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PIAS1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the PIAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PIAS1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O75925 |
| Purity: |
Antigen affinity |
| Description: |
It contains a putative zinc-binding motif and a highly acidic region, It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis, PIAS1 can also function as a SUMO ligase, PIAS1 inhibited STAT1-mediated gene activation in response to interferon when expressed in mammalian cells, This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1(signal transducer and activator of transcription-1)] family, or possibly as a tightly bound regulator of it, toward p53, E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene |
| Immunogen: |
mouse and rat), Amino acids 636-651 (DTASIFGIIPDIISLD-human) were used as the immunogen for this PIAS1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PIAS1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PIAS1 |
| Short name: |
PIAS1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PIAS1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2752 |
| Gene: |
PIAS1 |
More about : PIAS1 |
| Long gene name: |
protein inhibitor of activated STAT 1 |
| Synonyms gene: |
DDXBP1 |
| Synonyms gene name: |
DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 |
| Synonyms: |
GBP GU/RH-II ZMIZ3 |
| Synonyms name: |
MIZ-type containing 3 , zinc finger |
| Locus: |
15q23 |
| Discovery year: |
1998-11-06 |
| GenBank acession: |
AF077951 |
| Entrez gene record: |
8554 |
| Pubmed identfication: |
9724754 9177271 |
| Classification: |
Zinc fingers MIZ-type |
| Havana BLAST/BLAT: |
OTTHUMG00000172645 |