| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TIA-1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the TIA-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TIA-1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P31483 |
| Purity: |
Antigen affinity |
| Description: |
By in situ hybridization, It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets, It is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells, The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing, also called WDM, is an RNA-binding protein involved in splicing regulation and translational repression, the gene is mapped to chromosome 2p13, 3, TIA-1 (T-Cell Intracellular Antigen-1) |
| Immunogen: |
An amino acid sequence from the N-terminus of human TIA1 (STQRSQDHFHVFV) was used as the immunogen for this TIA-1 antibody (100% mouse homology) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TIA-1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TIA-1 |
| Short name: |
TIA-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TIA-1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11802 |
| Gene: |
TIA1 |
More about : TIA1 |
| Long gene name: |
TIA1 cytotoxic granule associated RNA binding protein |
| Synonyms gene name: |
TIA1 cytotoxic granule-associated RNA-binding protein |
| Synonyms name: |
T-cell-restricted intracellular antigen-1 nucleolysin TIA-1 isoform p40 |
| Locus: |
2p13, 3 |
| Discovery year: |
1995-11-01 |
| Entrez gene record: |
7072 |
| Pubmed identfication: |
8176212 12486009 |
| RefSeq identity: |
NM_022037 |
| Classification: |
RNA binding motif containing |
| Havana BLAST/BLAT: |
OTTHUMG00000129644 |