| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Hes1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Hes1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q14469 |
| Purity: |
Antigen affinity |
| Description: |
Hes1 may play a role in a functional FA core complex response to DNA cross-link damage, It is a transcriptional repressor of genes that require a bHLH protein for their transcription, The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box, This gene belongs to a family of basic helix-loop-helix (bHLH) proteins that are essential for neurogenesis, This gene is mapped to 3q29, This gene may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1, also called HRY, and sex determination, as well as for FANCD2 monoubiquitination in response to DNA damage, being required for the stability and nuclear localization of FA core complex proteins, hematopoiesis, is a protein that is encoded by the HES1 gene, myogenesis, Hairy and enhancer of split 1 |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human Hairy and enhancer of split 1 (HLANCMTQINAMTY) was used as the immunogen for this Hes1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Hes1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Hes1 |
| Short name: |
Hes1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
(Drosophila) (Antibody to), hairy and enhancer on split 1 |
| Alternative technique: |
antibodies |
| Identity: |
5192 |
| Gene: |
HES1 |
More about : HES1 |
| Long gene name: |
hes family bHLH transcription factor 1 |
| Synonyms gene: |
HRY |
| Synonyms gene name: |
(Drosophila) , hairy homolog (Drosophila) hairy and enhancer of split 1 |
| Synonyms: |
FLJ20408 HES-1 Hes1 bHLHb39 |
| Locus: |
3q29 |
| Discovery year: |
1993-09-21 |
| GenBank acession: |
L19314 |
| Entrez gene record: |
3280 |
| Pubmed identfication: |
8020957 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000155984 |