| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NCC (TSC) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-F, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the NCC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NCC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P55017 |
| Purity: |
Antigen affinity |
| Description: |
By fluorescence in situ hybridization, Mutations in this gene cause Gitelman syndrome, NCC is the target for thiazide diuretics that are used for treating high blood pressure, This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule, a disease similar to Bartter's syndrome, also called NCC (NaCl cotransporter) or TSC (Thiazide sensitive NaCl cotransporter), and increased renin activity associated with normal blood pressure, encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis, low urinary calcium, member 3, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, this gene is mapped to 16q13, Solute carrier family 12 (sodium/chloride transporters) |
| Immunogen: |
An amino acid sequence from the N-terminus of human NaCl Cotransporter protein (EDKASKGFFSYRADIFVQN) was used as the immunogen for this NCC antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NCC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NCC (TSC) |
| Short name: |
NCC Antibody (TSC) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NCC (Antibody to) (TSC) |
| Alternative technique: |
antibodies |
| Identity: |
26065 |
| Gene: |
TESC |
More about : TESC |
| Long gene name: |
tescalcin |
| Synonyms: |
TSC FLJ20607 CHP3 |
| Synonyms name: |
calcineurin-like EF hand protein 3 |
| Locus: |
12q24, 22 |
| Discovery year: |
2006-02-07 |
| GenBank acession: |
AF443207 |
| Entrez gene record: |
54997 |
| Pubmed identfication: |
11145610 11696366 12809501 14661968 |
| RefSeq identity: |
NM_017899 |
| Classification: |
EF-hand domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000144168 |