| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ANGPTL3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the ANGPTL3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ANGPTL3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9Y5C1 |
| Purity: |
Antigen affinity |
| Description: |
ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels, Angptl3 also acts as dual inhibitor of lipoprotein lipase(LPL) and endothelial lipase(EL), By radiation hybrid mapping and the use of surrounding genes, Conklin et al, It is predominantly expressed in the liver, N-terminal coiled-coil domain and the C-terminal fibrinogen(FBN)-like domain, The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors, also known as ANGPT5, and has the characteristic structure of angiopoietins, and increases plasma triglyceride and HDL cholesterol in rodents, consisting of a signal peptide, is a protein which in humans is encoded by the ANGPTL3 gene, (1999) mapped the gene to chromosome 1p31, Angiopoietin-Like 3 |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human Angiopoietin-Like 3 (EPKSRFAMLDDVKILAN) was used as the immunogen for this ANGPTL3 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ANGPTL3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ANGPTL3 |
| Short name: |
ANGPTL3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
angiopoietin-like 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ANGPTL3 and IDBG-638594 and ENSBTAG00000021386 and 782603, ANGPTL3 and IDBG-99367 and ENSG00000132855 and 27329, Angptl3 and IDBG-166252 and ENSMUSG00000028553 and 30924, Extracellular, growth factor activity, this GO :0004857 and enzyme inhibitor activity and molecular function this GO :0004859 and phospholipase inhibitor activity and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0006071 and glycerol metabolic process and biological process this GO :0006631 and fatty acid metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0009395 and phospholipid catabolic process and biological process this GO :0009725 and response to hormone and biological process this GO :0009986 and cell surface and cellular component this GO :0010519 and negative regulation of phospholipase activity and biological process this GO :0019915 and lipid storage and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0050996 and positive regulation of lipid catabolic process and biological process this GO :0051005 and negative regulation of lipoprotein lipase activity and biological process this GO :0055088 and lipid homeostasis and biological process this GO :0055090 and acylglycerol homeostasis and biological process this GO :0055091 and phospholipid homeostasis and biological process this GO :0070328 and triglyceride homeostasis and biological process, this GO :0004857 : enzyme inhibitor activity, this GO :0004857 : enzyme inhibitor activity and also this GO :0004859 : phospholipase inhibitor activity and also this GO :0005178 : integrin binding and also this GO :0008083 : growth factor activity, this GO :0004859 : phospholipase inhibitor activity, this GO :0005178 : integrin binding, this GO :0008083 : growth factor activity, angiopoietin-like 3 |
| Identity: |
491 |
| Gene: |
ANGPTL3 |
More about : ANGPTL3 |
| Long gene name: |
angiopoietin like 3 |
| Synonyms gene: |
ANGPT5 |
| Synonyms gene name: |
angiopoietin-like 3 |
| Synonyms name: |
angiopoietin 5 |
| Locus: |
1p31, 3 |
| Discovery year: |
2000-02-07 |
| GenBank acession: |
AF152562 |
| Entrez gene record: |
27329 |
| Pubmed identfication: |
10644446 |
| RefSeq identity: |
NM_014495 |
| Classification: |
Fibrinogen C domain containing Angiopoietin like |
| Havana BLAST/BLAT: |
OTTHUMG00000009146 |