| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CRTC2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the CRTC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CRTC2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q53ET0 |
| Purity: |
Antigen affinity |
| Description: |
By cotransfection of TORC2 and reporter genes in HeLa cells, Iourgenko et al, Liu et al, The International Radiation Hybrid Mapping Consortium mapped the gene to chromosome 1, Using mice and primary mouse hepatocytes, Wang et al, also known as TORC2, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin-1(SIRT1), is a protein that in humans is encoded by the CRTC2 gene, maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1, (2003) found that it potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences, (2008) demonstrated that a fasting-inducible switch, (2009) found that the protein functioned as a dual sensor for endoplasmic reticulum(ER) stress and fasting signals, CREB-Regulated Transcription Coactivator 2 |
| Immunogen: |
An amino acid sequence from the C-terminus of human CRTC2 (QDPHTFNHQNLTHCSRH) was used as the immunogen for this CRTC2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CRTC2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CRTC2 |
| Short name: |
CRTC2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CRTC2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
27301 |
| Gene: |
CRTC2 |
More about : CRTC2 |
| Long gene name: |
CREB regulated transcription coactivator 2 |
| Synonyms: |
TORC2 |
| Locus: |
1q21, 3 |
| Discovery year: |
2005-11-24 |
| GenBank acession: |
AY360172 |
| Entrez gene record: |
200186 |
| Pubmed identfication: |
14506290 14536081 |
| RefSeq identity: |
NM_181715 |
| Havana BLAST/BLAT: |
OTTHUMG00000037156 |