| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CRTC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the CRTC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CRTC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q6UUV9 |
| Purity: |
Antigen affinity |
| Description: |
By sequence analysis, Kovacs et al, Mair et al, TORC1 or KIAA0616, The prolongevity effects of activating AMPK or deactivating calcineurin decrease CRTC1 and CRH1 activity and induce transcriptional responses similar to those of CRH1-null worms, Tonon et al, also known as MECT1, and interacts with the CREB homolog-1(CRH1) transcription factor in vivo, and that it translocated to the nucleus upon concomitant activation of calcium and cAMP signaling pathways, is a protein that in humans is encoded by the CRTC1 gene, (2003) mapped the gene to chromosome 19p13, (2007) found that it was expressed in adult mouse brain and cultured neurons, (2011) demonstrated that CRTC1 is a direct AMPK target, CREB-Regulated Transcription Coactivator 1 |
| Immunogen: |
An amino acid sequence from the C-terminus of human CRTC1 (EQQMAARQANALSHQL) was used as the immunogen for this CRTC1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CRTC1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CRTC1 |
| Short name: |
CRTC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CRTC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16062 |
| Gene: |
CRTC1 |
More about : CRTC1 |
| Long gene name: |
CREB regulated transcription coactivator 1 |
| Synonyms gene: |
MECT1 |
| Synonyms gene name: |
mucoepidermoid carcinoma translocated 1 |
| Synonyms: |
KIAA0616 FLJ14027 TORC1 |
| Synonyms name: |
transducer of regulated cAMP response element-binding protein |
| Locus: |
19p13, 11 |
| Discovery year: |
2001-08-01 |
| GenBank acession: |
AY040323 |
| Entrez gene record: |
23373 |
| Pubmed identfication: |
12539049 14536081 14506290 |
| RefSeq identity: |
NM_025021 |
| Havana BLAST/BLAT: |
OTTHUMG00000183115 |