| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TRPV4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the TRPV4 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TRPV4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9HBA0 |
| Purity: |
Antigen affinity |
| Description: |
By genomic sequence analysis, Liedtke et al, OTRPC4 or VROAC, They mapped the mouse gene to distal chromosome 5 by radiation hybrid analysis, This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels, Wissenbach et al, also known as TRP12, is a protein that in humans is encoded by the TRPV4 gene, while hyperosmotic conditions inhibited the activity, (2000) found that hypoosmotic conditions rapidly activated TRP12, (2000) mapped the gene to chromosome 12q24, (2000) showed that TRPV4 was responsive to changes in extracellular osmolarity in the physiologically relevant range and was expressed in tissues exposed to changing osmotic environments, 1, Strotmann et al, Transient Receptor Potential Cation Channel Subfamily V Member 4 |
| Immunogen: |
mouse and rat), Amino acids 113-133 (YRHHSSDNKRWRKKIIEKQPQ) were used as the immunogen for this TRPV4 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TRPV4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TRPV4 |
| Short name: |
TRPV4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRPV4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18083 |
| Gene: |
TRPV4 |
More about : TRPV4 |
| Long gene name: |
transient receptor potential cation channel subfamily V member 4 |
| Synonyms gene name: |
member 4 , subfamily V, transient receptor potential cation channel |
| Synonyms: |
OTRPC4 TRP12 VROAC VRL-2 VR-OAC CMT2C |
| Synonyms name: |
osmosensitive transient receptor potential channel 4 |
| Locus: |
12q24, 11 |
| Discovery year: |
2002-01-29 |
| GenBank acession: |
AF263523 |
| Entrez gene record: |
59341 |
| Pubmed identfication: |
11025659 11081638 16382100 20037587 |
| RefSeq identity: |
NM_021625 |
| Classification: |
Ankyrin repeat domain containing Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000169277 |
| Locus Specific Databases: |
LRG_372 |