| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DLL1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the DLL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This DLL1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00548 |
| Purity: |
Antigen affinity |
| Description: |
Functional analysis by Han et al, Galceran et al, Gray et al, In contrast, It may play a role in cell-to-cell communication, It plays a role in mediating cell fate decisions during hematopoiesis, JAG1 did not disturb either B-cell or T-cell/NK-cell development, Jaleco et al, The protein is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family, Using FISH, also known as DL1 or DELTA1, and mutation of the Lef1 sites impaired expression of a reporter transgene in the presomitic mesoderm of embryonic mice, found that mouse Lef1 bound multiple sites in the DLL1 promoter in vitro and in vivo, is a protein that in humans is encoded by the DLL1 gene, near a locus for type I diabetes, (1999) mapped the gene to chromosome 6q27, (2000) suggested that a soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal amino acids increased the viability of hemopoietic cells but inhibited cell death, (2001) used a cell coculture assay to show that DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor, Delta-like 1 |
| Immunogen: |
Amino acids 168-184 (RTDLKYSYRFVCDEHYY-human) were used as the immunogen for this DLL1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DLL1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DLL1 |
| Short name: |
DLL1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
delta-like 1 (Drosophila) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DLL1 and IDBG-636101 and ENSBTAG00000031476 and 101908771, DLL1 and IDBG-99280 and ENSG00000198719 and 28514, Dll1 and IDBG-139653 and ENSMUSG00000014773 and 13388, Extracellular, protein binding, this GO :0001709 and cell fate determination and biological process this GO :0001756 and somitogenesis and biological process this GO :0001757 and somite specification and biological process this GO :0001947 and heart looping and biological process this GO :0005112 and Notch binding and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007154 and cell communication and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007368 and determination of left/right symmetry and biological process this GO :0007386 and compartment pattern specification and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0030097 and hemopoiesis and biological process this GO :0030154 and cell differentiation and biological process this GO :0030155 and regulation of cell adhesion and biological process this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0032693 and negative regulation of interleukin-10 production and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045608 and negative regulation of auditory receptor cell differentiation and biological process this GO :0045638 and negative regulation of myeloid cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045747 and positive regulation of Notch signaling pathway and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048839 and inner ear development and biological process this GO :0050767 and regulation of neurogenesis and biological process this GO :0070986 and left/right axis specification and biological process this GO :0072014 and proximal tubule development and biological process this GO :0072070 and loop of Henle development and biological process this GO :0097150 and neuronal stem cell maintenance and biological process, this GO :0005112 : Notch binding, this GO :0005112 : Notch binding and also this GO :0005509 : calcium ion binding and also this GO :0005515 : protein binding, this GO :0005509 : calcium ion binding, this GO :0005515 : protein binding, 788775, delta-like 1 (Drosophila) |
| Identity: |
2908 |
| Gene: |
DLL1 |
More about : DLL1 |
| Long gene name: |
delta like canonical Notch ligand 1 |
| Synonyms gene name: |
delta (Drosophila)-like 1 delta-like 1 (Drosophila) |
| Locus: |
6q27 |
| Discovery year: |
2000-02-11 |
| GenBank acession: |
AF003522 |
| Entrez gene record: |
28514 |
| Havana BLAST/BLAT: |
OTTHUMG00000016078 |