| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ABCC4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the ABCC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ABCC4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15439 |
| Purity: |
Antigen affinity |
| Description: |
ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus, By radiation hybrid analysis, Kool et al, Lee et al, Pharmacologic inhibition of protein activity or knockdown via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells, The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation, The protein belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells, Using FISH, Van de Ven et al, also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene, member 4, subfamily c, (1997) mapped the gene to chromosome 13, (1998) refined the localization to chromosome 13q32, (2008) concluded that the protein contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response, ATP-binding cassette |
| Immunogen: |
An amino acid sequence from the N-terminus of human ABCC4/MRP4 (WLNPLFKIGHKRRLEEDD) was used as the immunogen for this ABCC4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ABCC4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ABCC4 |
| Short name: |
ABCC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
member 4 (Antibody to), member 7)/MRP), sub-family C (cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C, adenosine triphosphate-binding cassette |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ABCC4 and IDBG-42534 and ENSG00000125257 and 10257, ATPase activity, Abcc4 and IDBG-186342 and ENSMUSG00000032849 and 239273, BT, MOAT-B and MOATB and MRP4, Plasma membranes, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances, coupled to transmembrane movement of substances and molecular function this GO :0048661 and positive regulation of smooth muscle cell proliferation and biological process this GO :0055085 and transmembrane transport and biological process this GO :0055114 and oxidation-reduction process and biological process, member 4, sub-family C (CFTR/MRP), this GO :0002576 and platelet degranulation and biological process this GO :0005524 and ATP binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006810 and transport and biological process this GO :0007596 and blood coagulation and biological process this GO :0008150 and biological process and biological process this GO :0010033 and response to organic substance and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016404 and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and molecular function this GO :0016887 and ATPase activity and molecular function this GO :0030168 and platelet activation and biological process this GO :0031088 and platelet dense granule membrane and cellular component this GO :0042493 and response to drug and biological process this GO :0042626 and ATPase activity, this GO :0005524 : ATP binding, this GO :0005524 : ATP binding and also this GO :0016404 : 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and also this GO :0016887 : ATPase activity and also this GO :0042626 : ATPase activity, this GO :0016404 : 15-hydroxyprostaglandin dehydrogenase (NAD+) activity, this GO :0016887 : ATPase activity, this GO :0042626 : ATPase activity, 93156 and IDBG-632162 and ENSBTAG00000032603 and 515333, ATP-binding cassette |
| Identity: |
55 |
| Gene: |
ABCC4 |
More about : ABCC4 |
| Long gene name: |
ATP binding cassette subfamily C member 4 |
| Synonyms gene name: |
ATP-binding cassette, member 4 , sub-family C (CFTR/MRP) |
| Synonyms: |
MRP4 EST170205 MOAT-B MOATB |
| Synonyms name: |
canalicular multispecific organic anion transporter (ABC superfamily) bA464I2, member 4) multidrug resistance-associated protein 4 multispecific organic anion transporter B , sub-family C (CFTR/MRP), 1 (ATP-binding cassette |
| Locus: |
13q32, 1 |
| Discovery year: |
1999-10-26 |
| GenBank acession: |
U66682 |
| Entrez gene record: |
10257 |
| Pubmed identfication: |
8894702 9661885 |
| RefSeq identity: |
NM_005845 |
| Classification: |
ATP binding cassette subfamily C |
| Havana BLAST/BLAT: |
OTTHUMG00000017216 |