| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SDHC |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the SDHC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SDHC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q99643 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Baysal et al, Elbehti-Green et al, Oostveen et al, The authors localized the human SDH3 gene to the short arm of chromosome one, also called SDH3, gene contains 6 exons, subunit C (SDHC), the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes, within 1 to 2 Mb from the centromere, without evidence of genomic imprinting, (1995) found that in fact it was protein from the bovine SDHC/SDH3 gene (encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation, (1998) confirmed the assignment of the SDHC gene to 1q21 by FISH, (2004) described a family with PGL3 in which an 8, 372-bp deletion in the SDHC gene was transmitted both maternally and paternally, The Succinate dehydrogenase complex |
| Immunogen: |
An amino acid sequence from the N-terminus of human Succinate dehydrogenase complex subunit C (KEEMERFWNKNIGSNR) was used as the immunogen for this SDHC antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SDHC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SDHC |
| Short name: |
SDHC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SDHC (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10682 |
| Gene: |
SDHC |
More about : SDHC |
| Long gene name: |
succinate dehydrogenase complex subunit C |
| Synonyms gene: |
PGL3 |
| Synonyms gene name: |
15kD succinate dehydrogenase complex, 15kDa , integral membrane protein, integral membrane protein, subunit C, subunit C, succinate dehydrogenase complex |
| Synonyms: |
CYB560 cybL |
| Synonyms name: |
succinate dehydrogenase cytochrome b560 subunit succinate dehydrgenase cytochrome b large subunit of cytochrome b |
| Locus: |
1q23, 3 |
| Discovery year: |
1997-10-21 |
| GenBank acession: |
D49737 |
| Entrez gene record: |
6391 |
| Pubmed identfication: |
9533030 12658451 |
| RefSeq identity: |
NM_003001 |
| Classification: |
Mitochondrial complex II: succinate dehydrogenase subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000034468 |
| Locus Specific Databases: |
SDHC @ LOVD TCA Cycle Gene Mutation Database LRG_317 |