| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ARC Apoptosis Repressor with CARD |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the ARC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ARC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O60936 |
| Purity: |
Antigen affinity |
| Description: |
-3, By genomic sequence analysis, CARD2 and MYP, Enzymatic analysis showed that ARC inhibits the enzymatic activity of CASP8, Immunoprecipitation and immunoblot analysis indicated that ARC interacts with CASP2 and -8 through its N-terminal death effector domain but does not interact with CASP1, It is reported that expression of the Apoptosis Repressor with CARD/ARC cDNA encoding the smaller transcript inhibited apoptosis in a dose-dependent manner when coexpressed with CASP8 but not when coexpressed with CASP9, NOL3, NOL3 has been shown to interact with SFRS9 and Caspase 8, NOP30, Stoss et al, The alternative 5-prime splice site that generates the two isoforms is located in exon 2, The protein also inhibited apoptosis induced by stimulation of CD95/FAS, also known as ARC, and TRAMP/death receptor-3, is a protein that in humans is encoded by the NOL3 gene, is composed of 4 exons, or -9, tumor necrosis factor receptor-1, which encodes NOP30 and MYP and which they called NOP, (1999) determined that the NOL3 gene, Apoptosis Repressor with CARD |
| Immunogen: |
Amino acids 91-106 (WDWQHVGPGYRDRSYD-human) were used as the immunogen for this ARC antibody (100% rat homology) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ARC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ARC Repressor with CARD |
| Short name: |
ARC Antibody Apoptosis Repressor with CARD |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
activity-regulated cytoskeleton-associated protein (Antibody to) programmed cellular destruction Repressor including CARD |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ARC and IDBG-37634 and ENSG00000198576 and 23237, ARC and IDBG-648018 and ENSBTAG00000021639 and 519403, Arc and IDBG-149967 and ENSMUSG00000022602 and 11838, Arg3, Cell surfaces, protein binding, this GO :0001669 and acrosomal vesicle and cellular component this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006897 and endocytosis and biological process this GO :0007010 and cytoskeleton organization and biological process this GO :0007492 and endoderm development and biological process this GO :0007612 and learning and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0015629 and actin cytoskeleton and cellular component this GO :0016477 and cell migration and biological process this GO :0022604 and regulation of cell morphogenesis and biological process this GO :0030054 and cell junction and cellular component this GO :0043197 and dendritic spine and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0048168 and regulation of neuronal synaptic plasticity and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, 1, activity-regulated cytoskeleton-associated protein |
| Identity: |
648 |
| Gene: |
ARC |
More about : ARC |
| Long gene name: |
activity regulated cytoskeleton associated protein |
| Synonyms: |
KIAA0278 Arg3, 1 |
| Locus: |
8q24, 3 |
| Discovery year: |
2000-05-23 |
| GenBank acession: |
AF193421 |
| Entrez gene record: |
23237 |
| Pubmed identfication: |
10970730 17466953 |
| Havana BLAST/BLAT: |
OTTHUMG00000134310 |