| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SNAP23 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-F, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the SNAP23 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SNAP23 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O00161 |
| Purity: |
Antigen affinity |
| Description: |
23-KD is a protein that in humans is encoded by the SNAP23 gene, After relocation, It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion, It is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs, Its amino acid sequence is 59% identical to that of SNAP25, Northern blot analysis revealed that SNAP23 is ubiquitously expressed, STX3A and SNAP23 were codistributed at the apical plasma membrane, TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells, The gene has 8 exons, The protein is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins, implying a crucial role in promoting membrane fusion, it is required for exocytosis, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin, with the initiation codon located in exon 2 and is mapped on 15q15, 1-q15, 2, Synaptosomal-Associated Protein |
| Immunogen: |
An amino acid sequence from the C-terminus of human SNAP23 (DTNRDRIDIANARAKKLIDS) was used as the immunogen for this SNAP23 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SNAP23 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SNAP23 |
| Short name: |
SNAP23 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
23kDa (Antibody to), synaptosomal-associated protein |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
23kDa, HsT17016 and SNAP-23 and SNAP23A and SNAP23B, SNAP23 and IDBG-646359 and ENSBTAG00000005661 and 100336178, SNAP23 and IDBG-7946 and ENSG00000092531 and 8773, Snap23 and IDBG-201120 and ENSMUSG00000027287 and 20619, nuclei, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006887 and exocytosis and biological process this GO :0006892 and post- this GO lgi vesicle-mediated transport and biological process this GO :0006903 and vesicle targeting and biological process this GO :0015031 and protein transport and biological process this GO :0030054 and cell junction and cellular component this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0042581 and specific granule and cellular component this GO :0042582 and azurophil granule and cellular component this GO :0043005 and neuron projection and cellular component this GO :0045087 and innate immune response and biological process this GO :0045202 and synapse and cellular component this GO :0061024 and membrane organization and biological process this GO :0061025 and membrane fusion and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding, 522423, synaptosomal-associated protein |
| Identity: |
11131 |
| Gene: |
SNAP23 |
More about : SNAP23 |
| Long gene name: |
synaptosome associated protein 23 |
| Synonyms gene name: |
23kDa , synaptosomal-associated protein |
| Synonyms: |
SNAP23A SNAP23B HsT17016 |
| Locus: |
15q15, 1-q15, 2 |
| Discovery year: |
1998-12-17 |
| GenBank acession: |
Y09567 |
| Entrez gene record: |
8773 |
| Pubmed identfication: |
9070898 8663154 |
| RefSeq identity: |
NM_003825 |
| Classification: |
SNAREs |
| Havana BLAST/BLAT: |
OTTHUMG00000130625 |