| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DUSP3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the DUSP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This DUSP3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P51452 |
| Purity: |
Antigen affinity |
| Description: |
Confocal microscopy demonstrated that phosphorylated VHR accumulated at the immune synapse between the T cell and the antigen-presenting cell in the presence of antigen, DUSP3 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP(mitogen-activated protein kinase phosphatase) class of DUSPs, DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues, DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily, The DUSP3 gene is mapped on 17q21, Tyrosine phosphorylation of VHR affects protein-protein interaction, also called VHR, given that tyr138 is located on the opposite side of the VHR catalytic center, is a member of the dual specificity protein phosphatase subfamily, or substrate targeting, subcellular location, 31, Dual-specificity phosphatase 3 |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human DUSP3(RQNREIGPNDGFLAQLC) was used as the immunogen for this DUSP3 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DUSP3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DUSP3 |
| Short name: |
DUSP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
dual specificity phosphatase 3 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DUSP3 and IDBG-52945 and ENSG00000108861 and 1845, DUSP3 and IDBG-640759 and ENSBTAG00000003966 and 615432, Dusp3 and IDBG-212400 and ENSMUSG00000003518 and 72349, MAP kinase phosphatase activity, VHR, nuclei, this GO :0000188 and inactivation of MAPK activity and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001772 and immunological synapse and cellular component this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004721 and phosphoprotein phosphatase activity and molecular function this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0008138 and protein tyrosine/serine/threonine phosphatase activity and molecular function this GO :0016311 and dephosphorylation and biological process this GO :0016791 and phosphatase activity and molecular function this GO :0033549 and MAP kinase phosphatase activity and molecular function this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045931 and positive regulation of mitotic cell cycle and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050860 and negative regulation of T cell receptor signaling pathway and biological process this GO :0050868 and negative regulation of T cell activation and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070373 and negative regulation of ERK1 and ERK2 cascade and biological process, this GO :0004721 : phosphoprotein phosphatase activity, this GO :0004721 : phosphoprotein phosphatase activity and also this GO :0004725 : protein tyrosine phosphatase activity and also this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity and also this GO :0016791 : phosphatase activity and also this GO :0033549 : MAP kinase phosphatase activity, this GO :0004725 : protein tyrosine phosphatase activity, this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity, this GO :0016791 : phosphatase activity, this GO :0033549 : MAP kinase phosphatase activity, dual specificity phosphatase 3 |
| Identity: |
3069 |
| Gene: |
DUSP3 |
More about : DUSP3 |
| Long gene name: |
dual specificity phosphatase 3 |
| Synonyms gene: |
VHR |
| Synonyms gene name: |
vaccinia virus phosphatase VH1-related |
| Locus: |
17q21, 31 |
| Discovery year: |
1994-05-19 |
| GenBank acession: |
BC035701 |
| Entrez gene record: |
1845 |
| Pubmed identfication: |
7829094 |
| RefSeq identity: |
NM_004090 |
| Classification: |
Atypical dual specificity phosphatases |
| Havana BLAST/BLAT: |
OTTHUMG00000180889 |