| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SIP |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the SIP antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SIP antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9HB71 |
| Purity: |
Antigen affinity |
| Description: |
It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins, It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin, SIP-short (SIPS), Sequence analysis of the shortest cDNA derived by 2-hybrid screening revealed an 8-amino acid difference in the deduced open reading frame followed by a stop codon, The C-terminal region of SIP that is homologous to SGT1 was able to complement defects in yeast strains containing SGT1 mutant alleles, The CACYBP gene is mapped on 1q25, The full-length SIP cDNA encodes a predicted 228-amino acid protein, Two alternatively spliced transcript variants encoding different isoforms have been found for this gene, also called SIP (SIAH Interacting Protein), demonstrating conservation of SGT1 and SIP protein function, is a protein that in humans is encoded by the CACYBP gene, resulting in a predicted 80-amino acid protein, 1, CACYBP (Calcyclin-binding protein) |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human SIAH Interacting Protein (NTRWDYLTQVEKECKE) was used as the immunogen for this SIP antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SIP antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SIP |
| Short name: |
SIP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SIP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30423 |
| Gene: |
CACYBP |
More about : CACYBP |
| Long gene name: |
calcyclin binding protein |
| Synonyms: |
SIP S100A6BP |
| Locus: |
1q25, 1 |
| Discovery year: |
2004-11-03 |
| GenBank acession: |
BC022352 |
| Entrez gene record: |
27101 |
| Pubmed identfication: |
11389839 12421809 |
| RefSeq identity: |
NM_014412 |
| Havana BLAST/BLAT: |
OTTHUMG00000034941 |