| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TRPC3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TRPC3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TRPC3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13507 |
| Purity: |
Antigen affinity |
| Description: |
It is part of endogenous calcium channels in T lymphocytes and contributes to T-cell receptor-dependent calcium entry into T cells, Neuropathologic studies showed impaired growth and differentiation of dendritic arbors of the Purkinje cells, Reduced calcium channel activity could be reversed by restoration of wildtype TRPC3, The TRPC3 gene, Using patch-clamp and whole-cell recordings of human embryonic kidney cells transfected with TRPC3, also known as TRP3, but not as a store-operated channel, but not other TRPC genes, is expressed in megakaryocytic cell lines and therefore may play a role in calcium homeostasis in megakaryocytes and platelets, member 3, resulting in expression of truncated transcripts, subfamily C, suggesting that normal TRPC3 plays a role in the development and survival of cerebellar Purkinje cells, the protein behaved as an inositol phosphate and diacylglycerol-gated channel, was damaged in several mutant T-cell lines with defective calcium influx, Transient receptor potential cation channel |
| Immunogen: |
mouse and rat), Amino acids 836-851 (HSFNSILNQPTRYQQI) were used as the immunogen for this TRPC3 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TRPC3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TRPC3 |
| Short name: |
TRPC3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRPC3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12335 |
| Gene: |
TRPC3 |
More about : TRPC3 |
| Long gene name: |
transient receptor potential cation channel subfamily C member 3 |
| Synonyms gene name: |
member 3 , subfamily C, transient receptor potential cation channel |
| Locus: |
4q27 |
| Discovery year: |
1995-09-01 |
| GenBank acession: |
Y13758 |
| Entrez gene record: |
7222 |
| Pubmed identfication: |
8646775 16382100 |
| RefSeq identity: |
NM_003305 |
| Classification: |
Transient receptor potential cation channels |
| Havana BLAST/BLAT: |
OTTHUMG00000133069 |