| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TGFBR1 (TGF beta Receptor I) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , Rat, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the TGFBR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TGFBR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P36897 |
| Purity: |
Antigen affinity |
| Description: |
Both are transmembrane serine/threonine receptor kinases, Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome(LDAS), TGFB1 regulates cell cycle progression by a unique signaling mechanism that involves its binding to TGFBR2 and activation of TGFBR1, TGFBR1 may be inactivated in many of the cases of human tumor cells refractory to TGFB-mediated cell cycle arrest, The encoded protein is a serine/threonine protein kinase, The organization of the segment of the gene that encodes the C-terminal portion of the serine/threonine kinase domain appears to be highly conserved among members of the gene family, The protein encoded by the TGFBR1 gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGFB, Vellucci and Reiss(1997) reported that the gene is approximately 31 kb long and contains 9 exons, beta receptor I is a TGFB receptor, transducing the TGFB signal from the cell surface to the cytoplasm, Transforming growth factor |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human TGF beta Receptor I (DYHEHGSLFDYLNRY) was used as the immunogen for this TGFBR1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TGFBR1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TGFBR1 (TGF beta Receptor I) |
| Short name: |
TGFBR1 Antibody (TGF beta Receptor I) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
b receptor 1 (Antibody to) (TGF b Receptor I), transforming growth factor |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AAT5 and ACVRLK4 and ALK-5 and ALK5 and ESS1 and LDS1 and LDS1A and LDS2A and MSSE and SKR4 and TGFR-1, Cell surfaces, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007165 and signal transduction and biological process this GO :0007178 and transmembrane receptor protein serine/threonine kinase signaling pathway and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007507 and heart development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008354 and germ cell migration and biological process this GO :0009435 and NAD biosynthetic process and biological process this GO :0009791 and post-embryonic development and biological process this GO :0009952 and anterior/posterior pattern specification and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010862 and positive regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016772 and transferase activity, DNA-templated and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046872 and metal ion binding and molecular function this GO :0048538 and thymus development and biological process this GO :0048663 and neuron fate commitment and biological process this GO :0048701 and embryonic cranial skeleton morphogenesis and biological process this GO :0048705 and skeletal system morphogenesis and biological process this GO :0048762 and mesenchymal cell differentiation and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0048870 and cell motility and biological process this GO :0050431 and transforming growth factor beta binding and molecular function this GO :0051272 and positive regulation of cellular component movement and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051897 and positive regulation of protein kinase B signaling and biological process this GO :0060017 and parathyroid gland development and biological process this GO :0060021 and palate development and biological process this GO :0060037 and pharyngeal system development and biological process this GO :0060389 and pathway-restricted SMAD protein phosphorylation and biological process this GO :0060391 and positive regulation of SMAD protein import into nucleus and biological process this GO :0070022 and transforming growth factor beta receptor homodimeric complex and cellular component this GO :0070411 and I-SMAD binding and molecular function this GO :0070723 and response to cholesterol and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process this GO :2001237 and negative regulation of extrinsic apoptotic signaling pathway and biological process, TGFBR1 and IDBG-634152 and ENSBTAG00000018035 and 282382, TGFBR1 and IDBG-78488 and ENSG00000106799 and 7046, Tgfbr1 and IDBG-146050 and ENSMUSG00000007613 and 21812, beta receptor 1, this GO :0000186 and activation of MAPKK activity and biological process this GO :0001501 and skeletal system development and biological process this GO :0001525 and angiogenesis and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001822 and kidney development and biological process this GO :0001824 and blastocyst development and biological process this GO :0001837 and epithelial to mesenchymal transition and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0002088 and lens development in camera-type eye and biological process this GO :0004514 and nicotinate-nucleotide diphosphorylase (carboxylating) activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004675 and transmembrane receptor protein serine/threonine kinase activity and molecular function this GO :0004702 and receptor signaling protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005024 and transforming growth factor beta-activated receptor activity and molecular function this GO :0005025 and transforming growth factor beta receptor activity, this GO :0004514 : nicotinate-nucleotide diphosphorylase (carboxylating) activity, this GO :0004514 : nicotinate-nucleotide diphosphorylase (carboxylating) activity and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity and also this GO :0004702 : receptor signaling protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005024 : transforming growth factor beta-activated receptor activity and also this GO :0005025 : transforming growth factor beta receptor activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004675 : transmembrane receptor protein serine/threonine kinase activity, this GO :0004702 : receptor signaling protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005024 : transforming growth factor beta-activated receptor activity, this GO :0005025 : transforming growth factor beta receptor activity, this GO :0005114 : type II transforming growth factor beta receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0019838 : growth factor binding, this GO :0046332 : SMAD binding, this GO :0046872 : metal ion binding, this GO :0050431 : transforming growth factor beta binding, this GO :0070411 : I-SMAD binding, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019838 : growth factor binding and also this GO :0046332 : SMAD binding and also this GO :0046872 : metal ion binding and also this GO :0050431 : transforming growth factor beta binding and also this GO :0070411 : I-SMAD binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019838 and growth factor binding and molecular function this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0032331 and negative regulation of chondrocyte differentiation and biological process this GO :0042060 and wound healing and biological process this GO :0043062 and extracellular structure organization and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043393 and regulation of protein binding and biological process this GO :0043542 and endothelial cell migration and biological process this GO :0045893 and positive regulation of transcription, transforming growth factor beta receptor activity, type I, type I and also this GO :0005114 : type II transforming growth factor beta receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, type I and molecular function this GO :0005114 and type II transforming growth factor beta receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005768 and endosome and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005923 and tight junction and cellular component this GO :0006355 and regulation of transcription, transforming growth factor |
| Identity: |
11772 |
| Gene: |
TGFBR1 |
More about : TGFBR1 |
| Long gene name: |
transforming growth factor beta receptor 1 |
| Synonyms gene: |
MSSE ESS1 |
| Synonyms gene name: |
multiple self-healing squamous epithelioma transforming growth factor beta receptor I |
| Synonyms: |
ALK-5 ACVRLK4 ALK5 |
| Synonyms name: |
53kDa , activin A receptor type II-like kinase |
| Locus: |
9q22, 33 |
| Discovery year: |
1993-09-30 |
| Entrez gene record: |
7046 |
| Pubmed identfication: |
1319842 8530052 21358634 |
| Classification: |
Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020353 |
| Locus Specific Databases: |
Belgium , Ghent, LOVD - Center for Medical Genetics |