| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HDC |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the HDC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This HDC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P23738 |
| Purity: |
Antigen affinity |
| Description: |
Ercan-Sencicek et al, The HDC gene is mapped on 15q21, The biogenic amine histamine is an important modulator of numerous physiologic processes, The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase, The deduced 662-amino acid protein has a molecular mass of 74, The gene contains 12 exons spanning approximately 24 kb, This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate, and smooth muscle tone, as well as increased anxiety, gastric acid secretion, including neurotransmission, noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, 148 Da, 2, Histidine decarboxylase is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6 |
| Immunogen: |
An amino acid sequence from the C-terminus of mouse Histidine decarboxylase (EQMMMMKKGAFKKLIKFYSV) was used as the immunogen for this HDC antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HDC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HDC |
| Short name: |
HDC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
histidine decarboxylase (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, HDC and IDBG-11604 and ENSG00000140287 and 3067, HDC and IDBG-646667 and ENSBTAG00000009911 and 515950, Hdc and IDBG-204118 and ENSMUSG00000027360 and 15186, pyridoxal phosphate binding, this GO :0001694 and histamine biosynthetic process and biological process this GO :0004398 and histidine decarboxylase activity and molecular function this GO :0005829 and cytosol and cellular component this GO :0006520 and cellular amino acid metabolic process and biological process this GO :0006547 and histidine metabolic process and biological process this GO :0006548 and histidine catabolic process and biological process this GO :0016831 and carboxy-lyase activity and molecular function this GO :0019752 and carboxylic acid metabolic process and biological process this GO :0030170 and pyridoxal phosphate binding and molecular function this GO :0034641 and cellular nitrogen compound metabolic process and biological process this GO :0042423 and catecholamine biosynthetic process and biological process this GO :0044281 and small molecule metabolic process and biological process, this GO :0004398 : histidine decarboxylase activity, this GO :0004398 : histidine decarboxylase activity and also this GO :0016831 : carboxy-lyase activity and also this GO :0030170 : pyridoxal phosphate binding, this GO :0016831 : carboxy-lyase activity, this GO :0030170 : pyridoxal phosphate binding, histidine decarboxylase |
| Identity: |
4855 |
| Gene: |
HDC |
More about : HDC |
| Long gene name: |
histidine decarboxylase |
| Locus: |
15q21, 2 |
| Discovery year: |
1990-12-19 |
| Entrez gene record: |
3067 |
| Pubmed identfication: |
1487235 |
| Havana BLAST/BLAT: |
OTTHUMG00000131644 |