| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NK1R Neurokinin 1 Receptor |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the NK1R antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NK1R antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P25103 |
| Purity: |
Antigen affinity |
| Description: |
Asp-Arg-Tyr, It is present in neurons, Lys/Arg-Lys/Arg-X-X-Lys/Arg, NK1R antagonists have also been studied in migraine, Tachykinin receptor 1, The NK1R can be found in both the central and peripheral nervous system, The binding of SP to NK1R has been associated with the transmission of stress signals and pain, The endogenous ligand for this receptor is Substance P, The loops have functional sites, The protein consists of 407 amino acid residues, The protein is the product of the TACR1 gene, also known as Neurokinin 1 receptor (NK1R) or Substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system, although it has some affinity for other tachykinins, an amino-terminus and a cytoplasmic carboxy-terminus, and it has a molecular weight of 58, as well as the other tachykinin receptors, brainstem, emesis and psychiatric disorders, gastrointestinal tracts, genitourinary tract, including two cysteines amino acids for a disulfide bridge, is made of seven hydrophobic transmembrane(TM) domains with three extracellular and three intracellular loops, muscle, pulmonary tissue, the contraction of smooth muscles and inflammation, thyroid gland and different types of immune cells, vascular endothelial cells, which interacts with G-proteins, which is responsible for association with arrestin and, 000, The Tachykinin receptor 1 (TACR1) |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human Neurokinin 1 Receptor (DSSDRYHEQVSAKRK) was used as the immunogen for this NK1R antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NK1R antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NK1R Neurokinin 1 Receptor |
| Short name: |
NK1R Antibody Neurokinin 1 Receptor |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NK1R (Antibody to) Neurokinin 1 Receptor |
| Alternative technique: |
antibodies |
| Identity: |
11526 |
| Gene: |
TACR1 |
More about : TACR1 |
| Long gene name: |
tachykinin receptor 1 |
| Synonyms gene: |
TAC1R |
| Synonyms: |
SPR NK1R NKIR |
| Locus: |
2p12 |
| Discovery year: |
1991-12-11 |
| GenBank acession: |
M76675 |
| Entrez gene record: |
6869 |
| Pubmed identfication: |
1657150 |
| RefSeq identity: |
NM_001058 |
| Classification: |
Tachykinin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000129973 |