| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NFAT1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the NFAT1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NFAT1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13469 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Ectopic expression of NFATC2/NFAT1 inhibited the basal activity of the human CDK4 promoter, NFAT1 controls myoblast fusion at a specific stage of myogenesis after the initial formation of a myotube and is necessary for further cell growth, NFATC2 is highly homologous to NFATC1 over a limited domain which shows similarity to the Dorsal/Rel family but has a wider tissue distribution, Overexpression of the protein promoted differentiation of osteoclast precursor cells into tartrate-resistant acid phosphatase-positive(TRAP-positive) multinucleated osteoclast-like cells even in the absence of RANKL, The NFATC2 gene is mapped on 20q13, also known as NFAT1 and NFATP or the preexisting component of NFAT, both Calna-/- and Nfatc2 -/- mice had elevated protein levels of Cdk4, confirming a negative regulatory role for the calcineurin/NFAT pathway, cytoplasmic 2, is present in the cytosolic fraction of unstimulated T cells and is a member of the nuclear factor of activated T cells (NFAT) family, 2, Nuclear factor of activated T-cells |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human NFAT1 (KQEQNLDQTYLDDVNEIIR) was used as the immunogen for this NFAT1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NFAT1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NFAT1 |
| Short name: |
NFAT1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NFAT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7776 |
| Gene: |
NFATC2 |
More about : NFATC2 |
| Long gene name: |
nuclear factor of activated T-cells 2 |
| Synonyms gene name: |
calcineurin-dependent 2 , cytoplasmic, nuclear factor of activated T-cells |
| Synonyms: |
NF-ATP NFATp NFAT1 |
| Locus: |
20q13, 2 |
| Discovery year: |
1994-11-16 |
| GenBank acession: |
U43342 U43341 |
| Entrez gene record: |
4773 |
| Pubmed identfication: |
8202141 |
| RefSeq identity: |
NM_012340 |
| Classification: |
Nuclear factors of activated T-cells |
| Havana BLAST/BLAT: |
OTTHUMG00000032747 |