| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HSD17B1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the HSD17B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This HSD17B1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P14061 |
| Purity: |
Antigen affinity |
| Description: |
All four isoforms are variably expressed in human anterior pituitary adenomas, HSD17B1 gene expression is detected in 34 of 42 (81%) adenomas in all tumor subtypes, HSD17B2 mRNA is detected in 18 of 42(43%) adenomas but not in prolactinomas, Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme, It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase, as demonstrated by kinetic studies, is an enzyme that is responsible for the interconversion of estrone(E1) and estradiol(E2) as well as the interconversion of androstenedione and testosterone, respectively, suggesting that it may play an important role in regulating the local cellular levels of estradiol, which also show HSD17B enzyme activity, 17-beta-Hydroxysteroid dehydrogenas I |
| Immunogen: |
Amino acids 29-43 (QSFKVYATLRDLKTQ-human) were used as the immunogen for this HSD17B1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HSD17B1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HSD17B1 |
| Short name: |
HSD17B1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HSD17B1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5210 |
| Gene: |
HSD17B1 |
More about : HSD17B1 |
| Long gene name: |
hydroxysteroid 17-beta dehydrogenase 1 |
| Synonyms gene: |
EDHB17 EDH17B2 |
| Synonyms gene name: |
hydroxysteroid (17-beta) dehydrogenase 1 |
| Synonyms: |
HSD17 MGC138140 SDR28C1 |
| Synonyms name: |
Estradiol 17-beta-dehydrogenase-1 short chain dehydrogenase/reductase family 28CE, member 1 |
| Locus: |
17q21, 2 |
| Discovery year: |
1991-06-05 |
| Entrez gene record: |
3292 |
| Pubmed identfication: |
2330005 19027726 |
| RefSeq identity: |
NM_000413 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000180243 |