| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
3-dioxygenase, IDO Indoleamine 2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the IDO antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This IDO antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P14902 |
| Purity: |
Antigen affinity |
| Description: |
By fluorescence in situ hybridization, During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, IDO-Interferon-gamma interaction has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine, also called INDO or IDO, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, at least partly because of the induction of indoleamine 2, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells, most notably IFNG, the assignment is narrowed to chromosome 8p12-p11, yielding an intermediate that deformylates to L-kynurenine, 3-dioxygenase, 3-dioxygenase, Indoleamine 2 |
| Immunogen: |
3-dioxygenase (MAHAMENSWTISKEYHIDEE) was used as the immunogen for this IDO antibody, An amino acid sequence from the N-terminus of human Indoleamine 2 |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the IDO antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
3-dioxygenase, IDO Indoleamine 2 |
| Short name: |
3-dioxygenase, IDO Antibody Indoleamine 2 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
3-dioxygenase, 3-dioxygenase 1 (Antibody to) Indoleamine 2, Indoleamine 2 |
| Alternative technique: |
antibodies |
| Identity: |
6059 |
| Gene: |
IDO1 |
More about : IDO1 |
| Long gene name: |
indoleamine 2, 3-dioxygenase 1 |
| Synonyms gene: |
IDO INDO |
| Synonyms gene name: |
indoleamine-pyrrole 2, 3 dioxygenase |
| Locus: |
8p11, 21 |
| Discovery year: |
1993-05-26 |
| GenBank acession: |
M34455 |
| Entrez gene record: |
3620 |
| Pubmed identfication: |
2109605 8404046 |
| RefSeq identity: |
NM_002164 |
| Havana BLAST/BLAT: |
OTTHUMG00000164057 |