| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CD168 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CD168 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CD168 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O75330 |
| Purity: |
Antigen affinity |
| Description: |
CD168 does not contain a membrane spanning domain nor does the mRNA transcript contain a signal sequence, CD44, Extracellularly, HMMR is less well studied than the main hyaluronan (HA) receptor, In contrast to CD44 and other cell-surface receptors which contain the classical membrane spanning domain and signal sequence for secretion from the endoplasmic reticulum/Golgi complex, Intracellularly, It normally is localized inside the cell and is only release by certain, RHAMM was originally discovered as a soluble protein that altered migratory cell behavior and bound to hyaluronan, The transport of CD168 to the extracellular space still is unclear but may involve transport channels or proteins, activates intracellular signaling pathways, and upon binding to HA, flippase activity, is a protein which in humans is encoded by the HMMR gene, it associates with CD44, it associates with microtubules and, or HMMR (Hyaluronan-mediated motility receptor), or exocytosis, plays a role in the regulation of mitosis, poorly defined stimuli, working with BRCA1 and BARD1, CD168 |
| Immunogen: |
An amino acid sequence from the C-terminus of human CD168 (KEGNTNCYRAPMECQESWK) was used as the immunogen for this CD168 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CD168 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CD168 |
| Short name: |
CD168 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD168 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5012 |
| Gene: |
HMMR |
More about : HMMR |
| Long gene name: |
hyaluronan mediated motility receptor |
| Synonyms gene name: |
hyaluronan-mediated motility receptor (RHAMM) hyaluronan-mediated motility receptor |
| Synonyms: |
RHAMM CD168 |
| Locus: |
5q34 |
| Discovery year: |
1995-11-14 |
| GenBank acession: |
U29343 |
| Entrez gene record: |
3161 |
| RefSeq identity: |
NM_012484 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000130381 |