| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TREM1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
IHC-F, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml (1), IHC (Frozen): 0, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
1, The chimeric recombinant protein used for testing contains AA 21-202 + human Fc and is glycosylated, Titration of the TREM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TREM1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9JKE2 |
| Purity: |
Antigen affinity |
| Description: |
CD40), Cross-linking of TREM1 on neutrophils induces interleukin-8(IL8) and myeloperoxidase secretion, Engagement also induces upregulation of adhesion molecules(e, Expression is seen is in monocytes and neutrophils but not in lymphocytes, ITGB1) and costimulatory molecules(e, MCP1 and TNF secretion could be further upregulated by LPS-mediated priming, TREM1 is associated with DAP12(TYROBP), The expression of Trem1 is upregulated by stimulation with lipopolysaccharide(LPS), a molecule frequently associated with activating receptors, and fungi, dendritic cells, gram-negative bacteria, is encoded by TREM1 gene, or SCYA2) and tumor necrosis factor(TNF), or other cell types, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1(MCP1, Triggering receptor expressed on myeloid cells-1, g, g |
| Immunogen: |
Amino acids 74-90 (FTRPSEVHMGKFTLKHD-mouse) were used as the immunogen for this TREM1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TREM1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TREM1 |
| Short name: |
TREM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
triggering receptor expressed on myeloid cells 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, TREM1 and IDBG-630874 and ENSBTAG00000017593 and 404547, TREM1 and IDBG-86629 and ENSG00000124731 and 54210, Trem1 and IDBG-189794 and ENSMUSG00000042265 and 58217, scaffold protein binding, this GO :0002374 and cytokine secretion involved in immune response and biological process this GO :0004872 and receptor activity and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006959 and humoral immune response and biological process this GO :0007596 and blood coagulation and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042107 and cytokine metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050755 and chemokine metabolic process and biological process this GO :0050900 and leukocyte migration and biological process this GO :0070945 and neutrophil mediated killing of gram-negative bacterium and biological process this GO :0072672 and neutrophil extravasation and biological process this GO :0097110 and scaffold protein binding and molecular function, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0097110 : scaffold protein binding, this GO :0097110 : scaffold protein binding, triggering receptor expressed on myeloid cells 1 |
| Identity: |
17760 |
| Gene: |
TREM1 |
More about : TREM1 |
| Long gene name: |
triggering receptor expressed on myeloid cells 1 |
| Synonyms: |
TREM-1 CD354 |
| Locus: |
6p21, 1 |
| Discovery year: |
2002-08-09 |
| GenBank acession: |
AF196329 |
| Entrez gene record: |
54210 |
| Pubmed identfication: |
11922939 10799849 |
| RefSeq identity: |
NM_018643 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000014674 |