| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DRD1 Dopamine Receptor D1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the Dopamine Receptor D1 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This DRD1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P21728 |
| Purity: |
Antigen affinity |
| Description: |
And the presence of a DRD1 gene restriction fragment length polymorphism will be helpful for future disease linkage studies, D1 and D2, D1Rs regulate neuron growth and differentiation, D2Rs inhibit adenylyl cyclase, DRD1/2 are targets of drug therapy in many psychomotor disorders, Receptors for dopamine have been classified into two functional types, They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins, This protein also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity, and may also have a role in drug addiction and alcoholism, but D1Rs stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases, including Parkinson's disease and schizophrenia, influence behaviour and modify DRD2-mediated events, Dopamine receptor D1 is the most highly expressed DA receptor subtype among the DA receptor family |
| Immunogen: |
Amino acids 221-242 (AQKQIRRIAALERAAVHAKNCQ-human) were used as the immunogen for this DRD1 antibody |
| Storage: |
After reconstitution, Avoid repeated freeze/thaws, Celcius or lower, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, The DRD1 antibody can be stored at 4oC to -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DRD1 Dopamine Receptor D1 |
| Short name: |
DRD1 Antibody Dopamine Receptor D1 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
dopamine receptor D1 (Antibody to) Dopamine Receptor D1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DADR and DRD1A, DRD1 and IDBG-58384 and ENSG00000184845 and 1812, DRD1 and IDBG-647825 and ENSBTAG00000047719 and 281125, Drd1a and IDBG-153258 and ENSMUSG00000021478 and 13488, coupled to cyclic nucleotide second messenger and biological process this GO :0007189 and adenylate cyclase-activating G-protein coupled receptor signaling pathway and biological process this GO :0007190 and activation of adenylate cyclase activity and biological process this GO :0007191 and adenylate cyclase-activating dopamine receptor signaling pathway and biological process this GO :0007212 and dopamine receptor signaling pathway and biological process this GO :0007416 and synapse assembly and biological process this GO :0007612 and learning and biological process this GO :0007613 and memory and biological process this GO :0007617 and mating behavior and biological process this GO :0007625 and grooming behavior and biological process this GO :0007626 and locomotory behavior and biological process this GO :0007628 and adult walking behavior and biological process this GO :0007631 and feeding behavior and biological process this GO :0008306 and associative learning and biological process this GO :0008542 and visual learning and biological process this GO :0010579 and positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway and biological process this GO :0014002 and astrocyte development and biological process this GO :0015872 and dopamine transport and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019226 and transmission of nerve impulse and biological process this GO :0019228 and neuronal action potential and biological process this GO :0021542 and dentate gyrus development and biological process this GO :0021756 and striatum development and biological process this GO :0021766 and hippocampus development and biological process this GO :0021853 and cerebral cortex GABAergic interneuron migration and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030432 and peristalsis and biological process this GO :0030819 and positive regulation of cAMP biosynthetic process and biological process this GO :0035106 and operant conditioning and biological process this GO :0035240 and dopamine binding and molecular function this GO :0042053 and regulation of dopamine metabolic process and biological process this GO :0042220 and response to cocaine and biological process this GO :0042311 and vasodilation and biological process this GO :0042417 and dopamine metabolic process and biological process this GO :0042493 and response to drug and biological process this GO :0042711 and maternal behavior and biological process this GO :0043268 and positive regulation of potassium ion transport and biological process this GO :0046323 and glucose import and biological process this GO :0046959 and habituation and biological process this GO :0046960 and sensitization and biological process this GO :0048148 and behavioral response to cocaine and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0051482 and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway and biological process this GO :0051584 and regulation of dopamine uptake involved in synaptic transmission and biological process this GO :0051968 and positive regulation of synaptic transmission, coupled via Gs, coupled via Gs and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004952 : dopamine receptor activity and also this GO :0005515 : protein binding and also this GO :0035240 : dopamine binding, coupled via Gs and molecular function this GO :0001659 and temperature homeostasis and biological process this GO :0001661 and conditioned taste aversion and biological process this GO :0001662 and behavioral fear response and biological process this GO :0001963 and synaptic transmission, dopamine receptor activity, dopaminergic and biological process this GO :0001975 and response to amphetamine and biological process this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004952 and dopamine receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006606 and protein import into nucleus and biological process this GO :0006936 and muscle contraction and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007187 and G-protein coupled receptor signaling pathway, glutamatergic and biological process this GO :0060134 and prepulse inhibition and biological process this GO :0060158 and phospholipase C-activating dopamine receptor signaling pathway and biological process this GO :0060291 and long-term synaptic potentiation and biological process this GO :0060292 and long term synaptic depression and biological process this GO :0071870 and cellular response to catecholamine stimulus and biological process, nuclei, this GO :0001588 and dopamine receptor activity, this GO :0001588 : dopamine receptor activity, this GO :0001588 : dopamine receptor activity, this GO :0004930 : G-protein coupled receptor activity, this GO :0004952 : dopamine receptor activity, this GO :0005515 : protein binding, this GO :0035240 : dopamine binding, dopamine receptor D1 |
| Identity: |
3020 |
| Gene: |
DRD1 |
More about : DRD1 |
| Long gene name: |
dopamine receptor D1 |
| Locus: |
5q35, 2 |
| Discovery year: |
1990-04-27 |
| GenBank acession: |
X55760 |
| Entrez gene record: |
1812 |
| RefSeq identity: |
NM_000794 |
| Classification: |
Dopamine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000130557 |