| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CUL1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CUL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CUL1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13616 |
| Purity: |
Antigen affinity |
| Description: |
3, 4A, Human CUL1, This is an essential component of the SCF(SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, This protein plays an important role in protein degradation and protein ubiquitination, and 5, but not the other closely related cullins 2, selectively interacts with human SKP1, signal transduction and transcription, which mediates the ubiquitination of proteins involved in cell cycle progression, Cullin 1 is a human protein and gene from cullin family |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human Cullin 1 (RQSMAKSRYMELYTHVYNY) was used as the immunogen for this CUL1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CUL1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CUL1 |
| Short name: |
CUL1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
cullin 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, CUL1 and IDBG-46918 and ENSG00000055130 and 8454, Cul1 and IDBG-143474 and ENSMUSG00000029686 and 26965, nuclei, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0005515 and protein binding and molecular function this GO :0005654 and nucleoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006513 and protein monoubiquitination and biological process this GO :0006915 and apoptotic process and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0008283 and cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0016032 and viral process and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019005 and SCF ubiquitin ligase complex and cellular component this GO :0031145 and anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0031146 and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0031461 and cullin-RING ubiquitin ligase complex and cellular component this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0051437 and positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0051439 and regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0031625 : ubiquitin protein ligase binding, this GO :0031625 : ubiquitin protein ligase binding, ubiquitin protein ligase binding, 36789 and IDBG-647000 and ENSBTAG00000047294 and, cullin 1 |
| Identity: |
2551 |
| Gene: |
CUL1 |
More about : CUL1 |
| Long gene name: |
cullin 1 |
| Locus: |
7q36, 1 |
| Discovery year: |
1998-10-29 |
| GenBank acession: |
U58087 |
| Entrez gene record: |
8454 |
| Pubmed identfication: |
8681378 |
| RefSeq identity: |
NM_003592 |
| Classification: |
Cullins SCF complex |
| Havana BLAST/BLAT: |
OTTHUMG00000152776 |