| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CaMKK |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CaMKK antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CaMKK antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q8VBY2 |
| Purity: |
Antigen affinity |
| Description: |
CaMKK binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity, Cotransfection of COS-7 cells with CaMKK and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone, It catalyzed a 10-fold increase in the total activity of CaMK1 and had no effect on CaMK2, The product of this gene belongs to the Serine/Threonine protein kinase family, This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade, Three transcript variants encoding two distinct isoforms have been identified for this gene, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily, suggesting that CaMKK enhances Camk4-mediated transcriptional regulation, Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene |
| Immunogen: |
Amino acids 10-31 (QDPRAELVDRVAAINVAHLEEA-mouse) were used as the immunogen for this CaMKK antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CaMKK antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CaMKK |
| Short name: |
CaMKK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CaMKK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1470 |
| Gene: |
CAMKK2 |
More about : CAMKK2 |
| Long gene name: |
calcium/calmodulin dependent protein kinase kinase 2 |
| Synonyms gene name: |
beta , calcium/calmodulin-dependent protein kinase kinase 2 |
| Synonyms: |
CAMKK KIAA0787 CAMKKB MGC15254 |
| Synonyms name: |
calcium/calmodulin-dependent protein kinase kinase beta |
| Locus: |
12q24, 31 |
| Discovery year: |
1999-08-27 |
| GenBank acession: |
AF101264 |
| Entrez gene record: |
10645 |
| Pubmed identfication: |
9662074 |
| RefSeq identity: |
NM_172226 |
| Havana BLAST/BLAT: |
OTTHUMG00000169156 |