| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Bcl10 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the Bcl10 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This Bcl10 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95999 |
| Purity: |
Antigen affinity |
| Description: |
10, 11 and 14, B-cell CLL/lymphoma 10, MALT1 and this protein are though to synergize in the activation of NF-kappaB, The BCL10 gene is mapped to chromosome 1p22, The protein encoded by this gene contains a caspase recruitment domain(CARD), This protein is found to form a complex with MALT1, This protein is reported to interact with other CARD domain containing proteins including CARD9, a protein encoded by another gene known to be translocated in MALT lymphoma, and has been shown to induce apoptosis and to activate NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue(MALT) lymphoma, which are though to function as upstream regulators in NF-kappaB signaling, BCL10 |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human Bcl10 (ERHFDHLRAKKILSRED) was used as the immunogen for this Bcl10 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Bcl10 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Bcl10 |
| Short name: |
Bcl10 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cellular CLL/lymphoma 10 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
989 |
| Gene: |
BCL10 |
More about : BCL10 |
| Long gene name: |
B-cell CLL/lymphoma 10 |
| Synonyms: |
CARMEN CIPER mE10 c-E10 CLAP |
| Synonyms name: |
CARD-like apoptotic protein CARD-containing apoptotic signaling protein CARD containing molecule enhancing NF-kB caspase-recruiting domain-containing protein CARD-containing proapoptotic protein |
| Locus: |
1p22, 3 |
| Discovery year: |
1999-01-08 |
| GenBank acession: |
AJ006288 |
| Entrez gene record: |
8915 |
| Pubmed identfication: |
9989495 |
| RefSeq identity: |
NM_003921 |
| Classification: |
Caspase recruitment domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000009965 |