| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CaMKK2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the CaMKK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CaMKK2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q96RR4 |
| Purity: |
Antigen affinity |
| Description: |
CaMKK2 regulates production of the appetite stimulating hormone neuropeptide Y and functions as an AMPK kinase in the hypothalamus, Inhibition of CaMKK2 in mice reduces appetite and promotes weight loss, It also has an important role in the development of hyperalgesia and tolerance to opioid analgesic drugs, The product of this gene belongs to the serine/threonine-specific protein kinase family, This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4, and to the Ca++/calmodulin-dependent protein kinase subfamily, is an enzyme that in humans is encoded by the CaMKK2 gene, through reduction in downstream signalling pathways and mu opioid receptor downregulation, Calcium/calmodulin-dependent protein kinase kinase 2 |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of CaMKK2 (KLAYNENDNTYYAMK) was used as the immunogen for this CaMKK2 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CaMKK2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CaMKK2 |
| Short name: |
CaMKK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CaMKK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1470 |
| Gene: |
CAMKK2 |
More about : CAMKK2 |
| Long gene name: |
calcium/calmodulin dependent protein kinase kinase 2 |
| Synonyms gene name: |
beta , calcium/calmodulin-dependent protein kinase kinase 2 |
| Synonyms: |
CAMKK KIAA0787 CAMKKB MGC15254 |
| Synonyms name: |
calcium/calmodulin-dependent protein kinase kinase beta |
| Locus: |
12q24, 31 |
| Discovery year: |
1999-08-27 |
| GenBank acession: |
AF101264 |
| Entrez gene record: |
10645 |
| Pubmed identfication: |
9662074 |
| RefSeq identity: |
NM_172226 |
| Havana BLAST/BLAT: |
OTTHUMG00000169156 |