| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Aromatase |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the Aromatase antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Aromatase antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P11511 |
| Purity: |
Antigen affinity |
| Description: |
By in situ hybridization, In particular, It is a member of the cytochrome P450 superfamily, It is an important factor in sexual development, Some bodybuilders taking steroids also take antiaromatase supplements to prevent excess testosterone conversion into estrogens, The CYP19 gene spans at least 70 kb of genomic DNA and contains 10 exons, The aromatase enzyme can be found in many tissues including gonads, adipose tissue, and endometrial cancer, and endometrium, aromatase is responsible for the aromatization of androgens into estrogens, as well as in tissue of endometriosis, blood vessels, bone, brain, breast cancer, placenta, skin, the ARO gene is mapped to 15q21, uterine fibroids, which are monooxygenases that catalyze many reactions involved in steroidogenesis, which can cause gynecomastia, 1, Aromatase is an enzyme responsible for a key step in the biosynthesis of estrogens |
| Immunogen: |
An amino acid sequence from the C-terminus of human Aromatase (KNMLEMIFTPRNSDRCLEH) was used as the immunogen for this Aromatase antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Aromatase antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Aromatase |
| Short name: |
Aromatase Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Aromatase (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2594 |
| Gene: |
CYP19A1 |
More about : CYP19A1 |
| Long gene name: |
cytochrome P450 family 19 subfamily A member 1 |
| Synonyms gene: |
CYP19 |
| Synonyms gene name: |
cytochrome P450, family 19, polypeptide 1 , subfamily A, subfamily XIX (aromatization of androgens) cytochrome P450 |
| Synonyms: |
ARO P-450AROM CPV1 ARO1 CYAR aromatase |
| Locus: |
15q21, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
D14473 |
| Entrez gene record: |
1588 |
| Pubmed identfication: |
8477708 |
| Classification: |
Cytochrome P450 family 19 |
| Havana BLAST/BLAT: |
OTTHUMG00000131747 |
| Locus Specific Databases: |
Human Cytochrome P450 (CYP) Allele Nomenclature Committee |