| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SOCS2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the SOCS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SOCS2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O14508 |
| Purity: |
Antigen affinity |
| Description: |
By cytogenetic and radiation hybrid mapping, GM-CSF, IL10 and interferon-gamma(IFN-gamma), Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control, SSI family members are cytokine-inducible negative regulators of cytokine signaling, The expression of this gene can be induced by a subset of cytokines, The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor(IGF1R), This gene encodes a member of the STAT-induced STAT inhibitor(SSI), Yandava et al, also known as suppressor of cytokine signalling(SOCS), and thus is though to be involved in the regulation of IGF1R mediated cell signaling, family, including erythropoietin, (1999) mapped the SOCS2 gene to chromosome 12q21, 3-q23, Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human SOCS2 (LPLPTRLKDYLEEYKFQV) was used as the immunogen for this SOCS2 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SOCS2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SOCS2 |
| Short name: |
SOCS2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
suppressor on cytokine signaling 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CIS2 and Cish2 and SOCS-2 and SSI-2 and SSI2 and STATI2, Cytoplasm, JAK pathway signal transduction adaptor activity, SOCS2 and IDBG-51299 and ENSG00000120833 and 8835, SOCS2 and IDBG-630845 and ENSBTAG00000012007 and 338437, this GO :0001558 and regulation of cell growth and biological process this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005131 and growth hormone receptor binding and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0007259 and JAK-STAT cascade and biological process this GO :0007568 and aging and biological process this GO :0008269 and JAK pathway signal transduction adaptor activity and molecular function this GO :0009966 and regulation of signal transduction and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0032355 and response to estradiol and biological process this GO :0032870 and cellular response to hormone stimulus and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043434 and response to peptide hormone and biological process this GO :0045087 and innate immune response and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0060396 and growth hormone receptor signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process, this GO :0005070 : SH3/SH2 adaptor activity, this GO :0005070 : SH3/SH2 adaptor activity and also this GO :0005131 : growth hormone receptor binding and also this GO :0005159 : insulin-like growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0008269 : JAK pathway signal transduction adaptor activity, this GO :0005131 : growth hormone receptor binding, this GO :0005159 : insulin-like growth factor receptor binding, this GO :0005515 : protein binding, this GO :0008269 : JAK pathway signal transduction adaptor activity, suppressor of cytokine signaling 2 |
| Identity: |
19382 |
| Gene: |
SOCS2 |
More about : SOCS2 |
| Long gene name: |
suppressor of cytokine signaling 2 |
| Synonyms: |
STATI2 SSI2 SOCS-2 SSI-2 CIS2 Cish2 |
| Synonyms name: |
STAT-induced STAT inhibitor-2 |
| Locus: |
12q |
| Discovery year: |
2002-11-13 |
| GenBank acession: |
AF037989 |
| Entrez gene record: |
8835 |
| Pubmed identfication: |
9344848 9266833 |
| Classification: |
Suppressors of cytokine signaling SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000170160 |