| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
HSD11B1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ICC, IHC-F, IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Frozen): 0, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0 |
| Notes: |
Titration of the HSD11B1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This HSD11B1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P28845 |
| Purity: |
Antigen affinity |
| Description: |
HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors, In these tissues, It is inhibited by carbenoxolone, Schutte et al, Tannin et al, The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe, a drug typically used in the treatment of peptic ulcers, adipose tissue, and the central nervous system, (1991) localized the HSD11B1 gene to chromosome 1, (2000) mapped the HSD11B1 gene to 1q32-q41, 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver |
| Immunogen: |
An amino acid sequence from the middle region of human HSD11B1 (DDIHHVRKSMEVNFL) was used as the immunogen for this HSD11B1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the HSD11B1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
HSD11B1 |
| Short name: |
HSD11B1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HSD11B1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5208 |
| Gene: |
HSD11B1 |
More about : HSD11B1 |
| Long gene name: |
hydroxysteroid 11-beta dehydrogenase 1 |
| Synonyms gene: |
HSD11B HSD11 |
| Synonyms gene name: |
hydroxysteroid (11-beta) dehydrogenase 1 |
| Synonyms: |
SDR26C1 |
| Synonyms name: |
member 1 , short chain dehydrogenase/reductase family 26C |
| Locus: |
1q32, 2 |
| Discovery year: |
1991-11-14 |
| GenBank acession: |
BC012593 |
| Entrez gene record: |
3290 |
| Pubmed identfication: |
1885595 19027726 |
| RefSeq identity: |
NM_005525 |
| Classification: |
Short chain dehydrogenase/reductase superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000036481 |