| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Phospholamban / PLN |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the Phospholamban antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Phospholamban antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P26678 |
| Purity: |
Antigen affinity |
| Description: |
Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site, McTiernan et al, Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells, The structure of the human phospholamban gene closely resembles that reported for chicken, The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, and mouse, rabbit, rat, thereby contributing to the inotropic response elicited in heart by beta-agonists, while the right atrium also expressed low levels of phospholamban, with markedly lower expression observed in smooth muscles, (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human Phospholamban (EKVQYLTRSAIRRAS) was used as the immunogen for this Phospholamban antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Phospholamban antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Phospholamban / PLN |
| Short name: |
Phospholamban Antibody / PLN |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Phospholamban (Antibody to) / PLN |
| Alternative technique: |
antibodies |
| Identity: |
9080 |
| Gene: |
PLN |
More about : PLN |
| Long gene name: |
phospholamban |
| Synonyms gene: |
PLB |
| Synonyms: |
CMD1P |
| Locus: |
6q22, 31 |
| Discovery year: |
1991-08-22 |
| Entrez gene record: |
5350 |
| Pubmed identfication: |
1828805 |
| RefSeq identity: |
NM_002667 |
| Havana BLAST/BLAT: |
OTTHUMG00000015462 |
| Locus Specific Databases: |
LRG_390 |