| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LXR alpha (NR1H3) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the LXR alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This LXR alpha antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13133 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, Furthermore, It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit, Liver X receptor activity is critical for physiologic lipid metabolism and transport, Liver X receptors act as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis, The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake, They are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease, also called NR1H3, is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity, they and their ligands are negative regulators of macrophage inflammatory gene expression, Liver X receptor alpha |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human LXR alpha (NVQDQLQVERLQHTY) was used as the immunogen for this LXR alpha antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the LXR alpha antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
LXR alpha (NR1H3) |
| Short name: |
LXR alpha Antibody (NR1H3) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
family H, member 3), LXR a (Antibody to) (nuclear receptor subfamily 1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0010467 and gene expression and biological process this GO :0010745 and negative regulation of macrophage derived foam cell differentiation and biological process this GO :0010867 and positive regulation of triglyceride biosynthetic process and biological process this GO :0010870 and positive regulation of receptor biosynthetic process and biological process this GO :0010875 and positive regulation of cholesterol efflux and biological process this GO :0010887 and negative regulation of cholesterol storage and biological process this GO :0015485 and cholesterol binding and molecular function this GO :0030522 and intracellular receptor signaling pathway and biological process this GO :0032270 and positive regulation of cellular protein metabolic process and biological process this GO :0032369 and negative regulation of lipid transport and biological process this GO :0032376 and positive regulation of cholesterol transport and biological process this GO :0032570 and response to progesterone and biological process this GO :0032810 and sterol response element binding and molecular function this GO :0034145 and positive regulation of toll-like receptor 4 signaling pathway and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042752 and regulation of circadian rhythm and biological process this GO :0043031 and negative regulation of macrophage activation and biological process this GO :0043277 and apoptotic cell clearance and biological process this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0044255 and cellular lipid metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045723 and positive regulation of fatty acid biosynthetic process and biological process this GO :0045861 and negative regulation of proteolysis and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048550 and negative regulation of pinocytosis and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0051006 and positive regulation of lipoprotein lipase activity and biological process this GO :0055088 and lipid homeostasis and biological process this GO :0055092 and sterol homeostasis and biological process this GO :0060336 and negative regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0070328 and triglyceride homeostasis and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process this GO :0090341 and negative regulation of secretion of lysosomal enzymes and biological process this GO :2000188 and regulation of cholesterol homeostasis and biological process this GO :2000189 and positive regulation of cholesterol homeostasis and biological process, LXR-a and LXRA and RLD-1, NR1H3 and IDBG-42877 and ENSG00000025434 and 10062, NR1H3 and IDBG-637355 and ENSBTAG00000010681 and 507176, Nr1h3 and IDBG-190792 and ENSMUSG00000002108 and 22259, group H, member 3, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978 : RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003707 : steroid hormone receptor activity and also this GO :0003713 : transcription coactivator activity and also this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0015485 : cholesterol binding and also this GO :0032810 : sterol response element binding and also this GO :0043565 : sequence-specific DNA binding and also this GO :0044212 : transcription regulatory region DNA binding, this GO :0001077 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677 : DNA binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003707 : steroid hormone receptor activity, this GO :0003713 : transcription coactivator activity, this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0015485 : cholesterol binding, this GO :0032810 : sterol response element binding, this GO :0043565 : sequence-specific DNA binding, this GO :0044212 : transcription regulatory region DNA binding, transcription regulatory region DNA binding, nuclear receptor subfamily 1 |
| Identity: |
7966 |
| Gene: |
NR1H3 |
More about : NR1H3 |
| Long gene name: |
nuclear receptor subfamily 1 group H member 3 |
| Synonyms gene name: |
group H, member 3 , nuclear receptor subfamily 1 |
| Synonyms: |
LXR-a RLD-1 |
| Synonyms name: |
liver X receptor-alpha |
| Locus: |
11p11, 2 |
| Discovery year: |
1999-09-17 |
| GenBank acession: |
U22662 |
| Entrez gene record: |
10062 |
| Pubmed identfication: |
8621574 7744246 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000150628 |