| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
NMDAR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the NMDAR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This NMDAR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q05586 |
| Purity: |
Antigen affinity |
| Description: |
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes, It consists of 21 exons distributed over about 31 kb, NMDA receptors are modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiologic and pathologic processes, NMDA(N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors, NMDAR1 gene is mapped to 9q34, The gene is a candidate for the site of the mutation in torsion dystonia, The promoter region contained 2 DNA binding sites for the homeobox proteins 'even-skipped', Three of the exons that are alternatively spliced in the rat and which produce 8 isoforms in that species were also present in the human sequence, such as excitotoxicity, 3 and encodes a 938-amino acid protein which showed high evolutionary conservation in structure and physiologic properties, The NMDA receptor is a non-specific cation channel and thus directly contributes to excitatory synaptic transmission by depolarizing the postsynaptic cell, The NMDA receptor(NMDAR) is a specific type of ionotropic glutamate receptor |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human NMDAR1 (RKHEQMFREAVNQANKRH) was used as the immunogen for this NMDAR1 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NMDAR1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
NMDAR1 |
| Short name: |
NMDAR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NMDAR1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4584 |
| Gene: |
GRIN1 |
More about : GRIN1 |
| Long gene name: |
glutamate ionotropic receptor NMDA type subunit 1 |
| Synonyms gene: |
NMDAR1 |
| Synonyms gene name: |
N-methyl D-aspartate 1 , N-methyl-D-aspartate receptor subunit NR1 glutamate receptor, ionotropic |
| Synonyms: |
GluN1 |
| Locus: |
9q34, 3 |
| Discovery year: |
1992-09-18 |
| Entrez gene record: |
2902 |
| Pubmed identfication: |
1350383 |
| RefSeq identity: |
NM_007327 |
| Classification: |
Glutamate ionotropic receptor NMDA type subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000020976 |