| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
COX2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the COX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This COX2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P35354 |
| Purity: |
Antigen affinity |
| Description: |
And the glucocorticoid receptor suppression of COX2 is also crucial for curtailing lethal immune activation, Cox-1 and Cox-2, Deletion of the gene in Min mice reduced the incidence of intestinal tumors, The COX2 gene encodes an inducible prostaglandin synthase enzyme that is overexpressed in adenocarcinomas and other tumors, This gene is localized to sites associated with retinal blood vessels, and plays an important role in blood vessel formation in the retina, and suggest new therapeutic approaches for regulation of T-cell-mediated inflammatory diseases, and two isoforms, have been identified, suggesting that it is required for tumorigenesis, Cyclooxygenase (Cox) is the key enzyme in conversion of arachidonic acid to PGs |
| Immunogen: |
An amino acid sequence from the N-terminus of human COX2 (CQNRGVCMSVGFDQYK) was used as the immunogen for this COX2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the COX2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
COX2 |
| Short name: |
COX2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
COX2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9605 |
| Gene: |
PTGS2 |
More about : PTGS2 |
| Long gene name: |
prostaglandin-endoperoxide synthase 2 |
| Synonyms gene name: |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| Synonyms: |
COX2 |
| Synonyms name: |
prostaglandin G/H synthase 2 cyclooxygenase 2 |
| Locus: |
1q31, 1 |
| Discovery year: |
1992-10-28 |
| GenBank acession: |
D28235 |
| Entrez gene record: |
5743 |
| Pubmed identfication: |
1380156 |
| RefSeq identity: |
NM_000963 |
| Havana BLAST/BLAT: |
OTTHUMG00000035473 |