| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Dicer |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the Dicer antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This Dicer antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
23405 |
| Purity: |
Antigen affinity |
| Description: |
Dicer also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs, In addition, It is mapped to 14q32, It is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression, The enzyme possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus, The gene, a member of the ribonuclease III (RNaseIII) family, is involved in the generation of microRNAs (miRNAs), it is required for formation of the RNA induced silencing complex (RISC), which modulate gene expression at the posttranscriptional level, 13, Dicer is an enzyme that in humans is encoded by the DICER1 gene |
| Immunogen: |
Human partial recombinant protein (AA 1-195) was used as the immunogen for this Dicer antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Dicer antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Dicer |
| Short name: |
Dicer Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Dicer (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7184 |
| Gene: |
MNG1 |
More about : MNG1 |
| Long gene name: |
dicer 1, ribonuclease III |
| Synonyms gene name: |
Dcr-1 homolog (Drosophila) multinodular goitre 1 dicer 1, Dicer1, ribonuclease type III |
| Synonyms: |
Dicer KIAA0928 K12H4, 8-LIKE HERNA DICER1 |
| Synonyms name: |
dicer 1, double-stranded RNA-specific endoribonuclease |
| Locus: |
14q32, 13 |
| Discovery year: |
2002-05-09 |
| GenBank acession: |
AB028449 |
| Entrez gene record: |
23405 |
| Pubmed identfication: |
10051563 10786632 21205968 |
| Classification: |
RNA helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000166134 |
| Locus Specific Databases: |
LRG_492 |