| Gene info: |
A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse, PUMA may be a direct mediator of p53-induced apoptosis, PUMA proteins bind Bcl-2, PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa, The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes, and PUMA&, and induce cytochrome c release and apoptosis in response to p53, localize to the mitochondria, which are also transcriptional targets of p53, #946, PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development |
| Gene names: |
JFY-1, PUMA, PUMA Antibody [10D4G7] : JFY1 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG |
| Ab raised in: |
Mouse |
| Type: |
Monoclonal |
| Monoclonal: |
10D4G7 |
| Immunoglobulin: |
IgG1 |
| Antigen: |
Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha |
| Immuno application: |
Western Blot, ELISA |
| Antibody advice: |
5 to 5 ug/mL, PUMA antibody can be used for detection of PUMA by Western blot at 2 |
| Suspention, pH, azide: |
02% sodium azide, PUMA Monoclonal Antibody is supplied in PBS containing 0 |
| Keep at: |
stable for one year, PUMA monoclonal antibody can be stored at -20 grades C |
| Works with: |
Rat, Human |
| Omim nr: |
56748610 |
| Ncbi nr: |
Q9BXH1 |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
27113 |
| GENE symbol: |
BBC3 |
| Antigene name: |
BCL2 binding component 3 |
| Source: |
Homo sapiens |
| Protein nr: |
Q9BXH1 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
PUMA [10D4G7] |
| Short name: |
anti-PUMA Antibody [10D4G7] |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-PUMA (Antibody to) [10D4G7] |
| Alternative technique: |
antibodies |
| Identity: |
17868 |
| Gene: |
BBC3 |
More about : BBC3 |
| Long gene name: |
BCL2 binding component 3 |
| Synonyms: |
JFY1 PUMA |
| Locus: |
19q13, 32 |
| Discovery year: |
2002-07-22 |
| GenBank acession: |
AF332558 |
| Entrez gene record: |
27113 |
| Pubmed identfication: |
11463392 11572983 |
| RefSeq identity: |
NM_014417 |
| Classification: |
BCL2 homology region 3 (BH3) only |
| Havana BLAST/BLAT: |
OTTHUMG00000183489 |