| Gene info: |
Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), Apaf1 can also associate with caspase-4 and caspase-8, Apaf1 transcript is ubiquitously expressed in human tissues, Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases, The mammalian homologous of the key cell death gene CED-4 in C, being responsible for the proteolytic cleavage of many key proteins in apoptosis, elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1, which leads to caspase-9 activation, Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands |
| Gene names: |
APAF-1, Apaf-1 Antibody [2E10] : CED4 |
| Antibodie's label: |
unlabelled serum |
| Purity: |
Apaf-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG |
| Ab raised in: |
Mouse |
| Type: |
Monoclonal |
| Monoclonal: |
2E10 |
| Antigen: |
A peptide corresponding to amino acids near the carboxy terminus of human Apaf1 |
| Immuno application: |
Western Blot, immuno-histo-chemistry, ELISA |
| Antibody advice: |
A 130 kDa band should be detected, Antibody can also be used for immunohistochemistry starting at 0, 25 - 0, 5 mg/mL, 5 ug/mL, Apaf1 antibody can be used for detection of Apaf1 by Western blot at 0 |
| Suspention, pH, azide: |
02% sodium azide, Apaf-1 Monoclonal Antibody is supplied in PBS containing 0 |
| Keep at: |
stable for one year, Apaf-1 monoclonal antibody can be stored at -20 grades C |
| Works with: |
Mouse, Rat, Human |
| Omim nr: |
2330015 |
| Ncbi nr: |
AAC51678 |
| KDa: |
130 kDa |
| Vial with antibody: |
in solution |
| Quantity per ml: |
1 mg/mL |
| NCBI GENE nr: |
317 |
| GENE symbol: |
APAF1 |
| Antigene name: |
apoptotic peptidase activating factor 1 |
| Source: |
Homo sapiens |
| Protein nr: |
O14727 |
| Description: |
Freeze thaw will destroy a percentage in every cycle and should be avoided, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4° |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by proscience they should be stored frozen at - 24° |
| Gene target: |
Apaf-1 [2E10] |
| Short name: |
anti-Apaf-1 Antibody [2E10] |
| Technique: |
antibodies against human proteins, antibodies for, antibody to, Antibody |
| Alternative name: |
antibody to-Apoptotic protease activating factor-1 (Antibody to) [2E10] |
| Alternative technique: |
antibodies |