| known also as: |
BCL2-like 11 apoptosis facilitator, Bcl2 interacting mediator of cell death), Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Anti-Bim |
| known also as: |
BCL2-like 11 apoptosis facilitator, Bcl2 interacting mediator of cell death), Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Bim |
| known also as: |
BCL2-like 11 apoptosis facilitator, Bcl2 interacting mediator of cell death), Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Bim |
| known also as: |
Bim |
| known also as: |
BCL2-like 11 apoptosis facilitator, Bcl2 interacting mediator of cell death), Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Anti -Bim |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Source: Human, Host: Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Detects endogenous levels of BIM only when phosphorylated at serine 69/65 |
| Purification method: |
Affinity Purified by immunoaffinity chromatography |
| Form/Appearance: |
0, 150mM sodium chloride, pH 7, 02% sodium azide and 50% glycerol, 4, Supplied as a liquid in PBS (without Mg2+ and Ca2+) |
| Storage and shipping: |
For maximum recovery of product, Further dilutions can be made in assay buffer, Under these conditions the aliquots will be stable for at least one year if kept at -20 °, centrifuge the original vial after thawing and prior to removing the cap, C, Long-term storage should be done after aliquoting the item and freezing the aliqotes at -20 degrees Celsius |
| Tested for:: |
Immunohistochemistry (IHC) |
| Description: |
For cells, cell lines and tissues in culture till half confluency, This 1 is suited for programmed cell-death studies |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
BCL2-like 11 facilitator, Bcl2 interacting mediator of death), Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Bim |
| Short name: |
BCL2-like 11 apoptosis facilitator, Bcl2 interacting mediator of death) Antibody, Bcl2l11, Ser69) (Bod, phosphorylated (Ser65, Bim |
| Technique: |
antibodies against human proteins, antibodies for, apoptosis pathway, apoptosis |
| Alternative name: |
B-cell CLL/lymphoma 2 interacting mediator on cellular death) (Antibody to), B-cell CLL/lymphoma 2-like 11 (apoptosis facilitator), B-cell CLL/lymphoma 2-like 11 programmed cellular destruction facilitator, Ser69) (Bod, phosphorylated (Ser65, Bim |
| Alternative technique: |
celldeath |
| Alternative to gene target: |
BCL2 and IDBG-4354 and ENSG00000171791 and 596, BCL2 and IDBG-645006 and ENSBTAG00000019302 and 281020, Bcl-2 and PPP1R50, Bcl2 and IDBG-185673 and ENSMUSG00000057329 and 12043, alpha-beta T cell lineage commitment and biological process this GO :0043473 and pigmentation and biological process this GO :0043496 and regulation of protein homodimerization activity and biological process this GO :0043497 and regulation of protein heterodimerization activity and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0043583 and ear development and biological process this GO :0045069 and regulation of viral genome replication and biological process this GO :0045087 and innate immune response and biological process this GO :0045636 and positive regulation of melanocyte differentiation and biological process this GO :0045930 and negative regulation of mitotic cell cycle and biological process this GO :0046671 and negative regulation of retinal cell programmed cell death and biological process this GO :0046902 and regulation of mitochondrial membrane permeability and biological process this GO :0046930 and pore complex and cellular component this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048041 and focal adhesion assembly and biological process this GO :0048066 and developmental pigmentation and biological process this GO :0048070 and regulation of developmental pigmentation and biological process this GO :0048087 and positive regulation of developmental pigmentation and biological process this GO :0048536 and spleen development and biological process this GO :0048538 and thymus development and biological process this GO :0048545 and response to steroid hormone and biological process this GO :0048546 and digestive tract morphogenesis and biological process this GO :0048589 and developmental growth and biological process this GO :0048599 and oocyte development and biological process this GO :0048743 and positive regulation of skeletal muscle fiber development and biological process this GO :0048753 and pigment granule organization and biological process this GO :0048873 and homeostasis of number of cells within a tissue and biological process this GO :0050790 and regulation of catalytic activity and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051434 and BH3 domain binding and molecular function this GO :0051607 and defense response to virus and biological process this GO :0051721 and protein phosphatase 2A binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0051902 and negative regulation of mitochondrial depolarization and biological process this GO :0051924 and regulation of calcium ion transport and biological process this GO :0055085 and transmembrane transport and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0071310 and cellular response to organic substance and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0072593 and reactive oxygen species metabolic process and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2000134 and negative regulation of G1/S transition of mitotic cell cycle and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001234 and negative regulation of apoptotic signaling pathway and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, leucine rich repeat containing receptor signaling pathway and biological process this GO :0040007 and growth and biological process this GO :0040018 and positive regulation of multicellular organism growth and biological process this GO :0042100 and B cell proliferation and biological process this GO :0042149 and cellular response to glucose starvation and biological process this GO :0042493 and response to drug and biological process this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043029 and T cell homeostasis and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043067 and regulation of programmed cell death and biological process this GO :0043085 and positive regulation of catalytic activity and biological process this GO :0043209 and myelin sheath and cellular component this GO :0043375 and CD8-positive, nuclei, protein phosphatase 2A binding, this GO :0000209 and protein polyubiquitination and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0001101 and response to acid and biological process this GO :0001503 and ossification and biological process this GO :0001541 and ovarian follicle development and biological process this GO :0001656 and metanephros development and biological process this GO :0001657 and ureteric bud development and biological process this GO :0001658 and branching involved in ureteric bud morphogenesis and biological process this GO :0001662 and behavioral fear response and biological process this GO :0001776 and leukocyte homeostasis and biological process this GO :0001782 and B cell homeostasis and biological process this GO :0001822 and kidney development and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0001952 and regulation of cell-matrix adhesion and biological process this GO :0002020 and protease binding and molecular function this GO :0002260 and lymphocyte homeostasis and biological process this GO :0002320 and lymphoid progenitor cell differentiation and biological process this GO :0002326 and B cell lineage commitment and biological process this GO :0002360 and T cell lineage commitment and biological process this GO :0002520 and immune system development and biological process this GO :0002931 and response to ischemia and biological process this GO :0003014 and renal system process and biological process this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0006582 and melanin metabolic process and biological process this GO :0006808 and regulation of nitrogen utilization and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006959 and humoral immune response and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007015 and actin filament organization and biological process this GO :0007409 and axonogenesis and biological process this GO :0007565 and female pregnancy and biological process this GO :0007569 and cell aging and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008584 and male this GO nad development and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0009314 and response to radiation and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009791 and post-embryonic development and biological process this GO :0009887 and organ morphogenesis and biological process this GO :0010039 and response to iron ion and biological process this GO :0010224 and response to UV-B and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010507 and negative regulation of autophagy and biological process this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0010559 and regulation of glycoprotein biosynthetic process and biological process this GO :0014031 and mesenchymal cell development and biological process this GO :0014042 and positive regulation of neuron maturation and biological process this GO :0014911 and positive regulation of smooth muscle cell migration and biological process this GO :0015267 and channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016049 and cell growth and biological process this GO :0016248 and channel inhibitor activity and molecular function this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019903 and protein phosphatase binding and molecular function this GO :0021747 and cochlear nucleus development and biological process this GO :0022612 and gland morphogenesis and biological process this GO :0022898 and regulation of transmembrane transporter activity and biological process this GO :0030097 and hemopoiesis and biological process this GO :0030183 and B cell differentiation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0030279 and negative regulation of ossification and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031103 and axon regeneration and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031647 and regulation of protein stability and biological process this GO :0031965 and nuclear membrane and cellular component this GO :0031966 and mitochondrial membrane and cellular component this GO :0032469 and endoplasmic reticulum calcium ion homeostasis and biological process this GO :0032835 and glomerulus development and biological process this GO :0032848 and negative regulation of cellular pH reduction and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033077 and T cell differentiation in thymus and biological process this GO :0033138 and positive regulation of peptidyl-serine phosphorylation and biological process this GO :0033689 and negative regulation of osteoblast proliferation and biological process this GO :0034097 and response to cytokine and biological process this GO :0035094 and response to nicotine and biological process this GO :0035265 and organ growth and biological process this GO :0035872 and nucleotide-binding domain, this GO :0002020 : protease binding, this GO :0002020 : protease binding and also this GO :0005515 : protein binding and also this GO :0008134 : transcription factor binding and also this GO :0015267 : channel activity and also this GO :0016248 : channel inhibitor activity and also this GO :0019903 : protein phosphatase binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding and also this GO :0051721 : protein phosphatase 2A binding, this GO :0005515 : protein binding, this GO :0008134 : transcription factor binding, this GO :0015267 : channel activity, this GO :0016248 : channel inhibitor activity, this GO :0019903 : protein phosphatase binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0043565 : sequence-specific DNA binding, this GO :0046982 : protein heterodimerization activity, this GO :0051434 : BH3 domain binding, this GO :0051721 : protein phosphatase 2A binding, B-cell CLL/lymphoma 2 |
| Identity: |
990 |
| Gene: |
BCL2 |
More about : BCL2 |
| Long gene name: |
BCL2, apoptosis regulator |
| Synonyms gene name: |
B-cell CLL/lymphoma 2 |
| Synonyms: |
Bcl-2 PPP1R50 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 50 |
| Locus: |
18q21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M14745 |
| Entrez gene record: |
596 |
| RefSeq identity: |
NM_000633 NM_000657 |
| Classification: |
Protein phosphatase 1 regulatory subunits BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000132791 |
| Locus Specific Databases: |
LRG_1113 |