| Also known as: |
PML ring finger domain |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PML |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
k, IgG1 |
| Clone: |
B4C8 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
(alpha) chimeric protein in promyelocytic leukemia patients, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, and also recognizes the high molecular weight PML/RAR&, anti-human [Ring Finger Domain] <, #945, /b>, Promyeloctic Leukemia (PML), Specificity Note: <, This antibody recognizes normal PML proteins of lower molecular weight, b> |
| Form/Appearance: |
0, Lyophilized in pH 7, To reconstitute, add appropriate volume of dIH2O to reach a final antibody concentration of 1mg/ml, 01M PBS, 4, Affinity Purified |
| Storage and shipping: |
Avoid repeated freeze/thaw cycles, Store in aliquots the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
Western Blot, ELISA |
| Description: |
Finger like and finger proteins are like zinc fingers , Freeze thaw will destroy a percentage in every cycle and should be avoided, Homeobox and homeodomain families, C in a fridge short term in a concentrated dilution, This antibody needs to be stored at + 4°, coordination , in order to stabilize the fold, ions , of one or more , proteins with a , small , structural motif , that is characterized by the , zinc |
| French translation: |
anticorps |
| Gene target: |
PML ring finger domain monoclonal [B4C8] |
| Short name: |
Purified mouse anti-human PML ring finger domain monoclonal antibody [B4C8] |
| Technique: |
antibody to, anti |
| Host: |
mouse |
| Alternative name: |
sapiens promyelocytic leukemia ring finger domain monoclonal (Antibody to) [B4C8], enriched mouse antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006461 and protein complex assembly and biological process this GO :0006605 and protein targeting and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006977 and DNA damage response, DNA-templated and biological process this GO :0045930 and negative regulation of mitotic cell cycle and biological process this GO :0046332 and SMAD binding and molecular function this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048384 and retinoic acid receptor signaling pathway and biological process this GO :0050821 and protein stabilization and biological process this GO :0050897 and cobalt ion binding and molecular function this GO :0051457 and maintenance of protein location in nucleus and biological process this GO :0051607 and defense response to virus and biological process this GO :0051974 and negative regulation of telomerase activity and biological process this GO :0060058 and positive regulation of apoptotic process involved in mammary gland involution and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060444 and branching involved in mammary gland duct morphogenesis and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0071353 and cellular response to interleukin-4 and biological process this GO :0072332 and intrinsic apoptotic signaling pathway by p53 class mediator and biological process this GO :0090398 and cellular senescence and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :1902187 and negative regulation of viral release from host cell and biological process this GO :2000059 and negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :2000779 and regulation of double-strand break repair and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process this GO :2001238 and positive regulation of extrinsic apoptotic signaling pathway and biological process, MYL and PP8675 and RNF71 and TRIM19, PML and IDBG-21462 and ENSG00000140464 and 5371, PML and IDBG-631902 and ENSBTAG00000015779 and 100138545, Pml and IDBG-171712 and ENSMUSG00000036986 and 18854, cobalt ion binding, nuclei, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007182 and common-partner SMAD protein phosphorylation and biological process this GO :0007184 and SMAD protein import into nucleus and biological process this GO :0007569 and cell aging and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0009411 and response to UV and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010522 and regulation of calcium ion transport into cytosol and biological process this GO :0016032 and viral process and biological process this GO :0016363 and nuclear matrix and cellular component this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0016605 and PML body and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030308 and negative regulation of cell growth and biological process this GO :0030578 and PML body organization and biological process this GO :0031065 and positive regulation of histone deacetylation and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0031901 and early endosome membrane and cellular component this GO :0031965 and nuclear membrane and cellular component this GO :0032183 and SUMO binding and molecular function this GO :0032211 and negative regulation of telomere maintenance via telomerase and biological process this GO :0032469 and endoplasmic reticulum calcium ion homeostasis and biological process this GO :0032922 and circadian regulation of gene expression and biological process this GO :0032938 and negative regulation of translation in response to oxidative stress and biological process this GO :0034097 and response to cytokine and biological process this GO :0042406 and extrinsic component of endoplasmic reticulum membrane and cellular component this GO :0042752 and regulation of circadian rhythm and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043153 and entrainment of circadian clock by photoperiod and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045343 and regulation of MHC class I biosynthetic process and biological process this GO :0045892 and negative regulation of transcription, this GO :0001666 and response to hypoxia and biological process this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0002230 and positive regulation of defense response to virus by host and biological process this GO :0003677 and DNA binding and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003713 : transcription coactivator activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0032183 : SUMO binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046332 : SMAD binding and also this GO :0046982 : protein heterodimerization activity and also this GO :0050897 : cobalt ion binding, this GO :0003713 : transcription coactivator activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0032183 : SUMO binding, this GO :0042803 : protein homodimerization activity, this GO :0046332 : SMAD binding, this GO :0046982 : protein heterodimerization activity, this GO :0050897 : cobalt ion binding, promyelocytic leukemia |
| Identity: |
9113 |
| Gene: |
PML |
More about : PML |
| Long gene name: |
promyelocytic leukemia |
| Synonyms: |
MYL TRIM19 RNF71 |
| Locus: |
15q24, 1 |
| Discovery year: |
1991-06-05 |
| GenBank acession: |
AB208950 |
| Entrez gene record: |
5371 |
| RefSeq identity: |
NM_002675 |
| Classification: |
Tripartite motif containing Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000137607 |
| Locus Specific Databases: |
LRG_1069 |