| Also known as: |
vitronectin receptor CD51 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
NKI-M7 (former AMF7) |
| Host organism: |
Mouse (Mus musculus) (Balb/c) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
29 and 25 kDa respectively, 95, In addition to their membrane localization, NKI-M7 blocks fibronectin-induced chemotaxic motility and chemokinesis of melanoma cells, NKI-M7 reacts with cultured melanomas melanomas in frozen sections, NKI-M7 stains primary tumors heterogeneously, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells, This particular antibody might cross react with speacies outside of the listed ones, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells, whereas metastases are homogeneously stained, which under reducing conditions consists of 4 compounds of 120, T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex |
| Form/Appearance: |
09% sodium azide, Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0 |
| Storage and shipping: |
or in small aliquots the antibody should be stored at -20 degrees Celsius, Store the antibody at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP), ELISA (EIA) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, Homo sapiens sapiens), Human proteins, humans , ssp |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
vitronectin receptor CD51 |
| Short name: |
Mouse Anti- vitronectin receptor CD51 |
| Technique: |
mouses, Mouse |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
sapiens vitronectin receptor CD51, Mouse antibody to-H |
| Alternative technique: |
murine |
| Identity: |
6150 |
| Gene: |
ITGAV |
More about : ITGAV |
| Long gene name: |
integrin subunit alpha V |
| Synonyms gene: |
VNRA MSK8 VTNR |
| Synonyms gene name: |
alpha V , alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) integrin, antigen identified by monoclonal antibody L230 vitronectin receptor integrin |
| Synonyms: |
CD51 |
| Locus: |
2q32, 1 |
| Discovery year: |
1988-07-19 |
| Entrez gene record: |
3685 |
| Pubmed identfication: |
2454952 |
| RefSeq identity: |
NM_002210 |
| Classification: |
Integrin alpha subunits CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000132635 |