| Also known as: |
pS2 |
| Other names: |
Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1, Protein pS2, Trefoil factor 1, breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, gastrointestinal trefoil protein pS2, hP1, polypeptide P1, protein pS2, trefoil factor 1, trefoil factor 1, A, A, A, trefoil factor 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TFF1 |
| Other gene names: |
BCEI, BCEI, D21S21, HP1, HPS2, PS2, TFF1, hP1, pNR-2, pS2, A, A, TFF1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa, IgG1 |
| Clone: |
SPM573 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Cynomolgus Monkey, Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
About 60% of breast carcinomas are positive for pS2, Its epitope is localized between aa57-84 of human pS2 protein, Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Staining is cytoplasmic, These peptides contain three intrachain disulfide bonds, This particular antibody might cross react with speacies outside of the listed ones, Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing, and in ulcerations of the gastrointestinal tract, forming the trefoil motif, gastric fluid, goblet cells in the colon and small intestine, identified as pS2 estrogen-regulated protein, often with localization to the Golgi apparatus, or P-domain, pS2 is a trefoil peptide, pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties, pS2 is shown to be localized in normal stomach mucosa, 5kDa, It recognizes a polypeptide of 6 |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA) |
| Gene target: |
pS2/ pNR-2/ Trefoil Factor 1 |
| Short name: |
pS2/ pNR-2/ Trefoil Factor 1 |
| Alternative name: |
pS2/ pNR-2/ Trefoil Factor 1 |