| Also known as: |
1, TTF-1/ NKX2 |
| Other names: |
Homeobox protein NK-2 homolog A, Homeobox protein Nkx-2, NK-2 homolog A, NK2 homeobox 1, T/EBP, TTF-1, Thyroid nuclear factor 1, Thyroid transcription factor 1, Thyroid-specific enhancer-binding protein, homeobox protein NK-2 homolog A, homeobox protein Nkx-2, thyroid nuclear factor 1, thyroid transcription factor 1, thyroid-specific enhancer-binding protein, 1, 1, 1 isoform 1, homeobox protein Nkx-2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
NKX2-1 |
| Other gene names: |
BCH, BHC, NK-2, NKX2, NKX2-1, NKX2A, NKX2A, T/EBP, T/EBP, TEBP, TITF1, TITF1, TTF-1, TTF-1, TTF1, TTF1, 1, NKX2-1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
kappa, IgG1 |
| Clone: |
8G7G3/1 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, Mouse (Mus musculus), Rat (Rattus norvegicus), Shows a broad species reactivity, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates, It is expressed in epithelial cells of the thyroid gland and the lung, Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms, Nuclei from liver, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, TTF-1 is a member of the NKx2 family of homeodomain transcription factors, TTF-1 reactivity is also seen in thyroid malignancies, This particular antibody might cross react with speacies outside of the listed ones, and adrenal glands are unreactive, and malignant mesothelioma, breast, colon, identified as Thyroid transcription factor-1 (TTF-1), kidney, mediastinal germ cell tumors, pancreas, pituitary, prostate, skin, small intestine, stomach, testes, Recognizes a protein of 40kDa |
| Storage and shipping: |
Antibody is stable for 24 months, Temperature variations in the range of 1 to 7 degrees Celsius are tolerable, We recommend NOT to freeze the antibody, Store the antibody at +4C |
| Tested applications:: |
Immunofluorescence (IF), Immunohistology (IH), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS) |
| Gene target: |
1, TTF-1/ NKX2 |
| Short name: |
1, TTF-1/ NKX2 |
| Alternative name: |
1, TTF-1/ NKX2 |
| Identity: |
11825 |
| Gene: |
NKX2-1 |
More about : NKX2-1 |
| Long gene name: |
NK2 homeobox 1 |
| Synonyms gene: |
NKX2A BCH TITF1 |
| Synonyms gene name: |
benign chorea thyroid transcription factor 1 |
| Synonyms: |
TTF-1 TTF1 |
| Locus: |
14q13, 3 |
| Discovery year: |
1992-06-12 |
| Entrez gene record: |
7080 |
| Pubmed identfication: |
1976511 |
| RefSeq identity: |
NM_003317 |
| Classification: |
NKL subclass homeoboxes and pseudogenes |
| Havana BLAST/BLAT: |
OTTHUMG00000140225 |