| known also as: |
Anti-PTEN-Induced Kinase (PINK1) |
| known also as: |
PTEN-Induced Kinase (PINK1) |
| known also as: |
PTEN-Induced Kinase (PINK1) |
| known also as: |
PTEN-Induced Kinase |
| known also as: |
Anti -PTEN-Induced Kinase (PINK1) |
| Other names: |
CG4523 gene product from transcript CG4523-RH, CG4523-PA, CG4523-PB, CG4523-PC, CG4523-PD, CG4523-PE, CG4523-PF, CG4523-PG, CG4523-PH, N/A, N/A, PTEN induced putative kinase 1, PTEN-Induced kinase 1, PTEN-induced putative kinase 1, PTEN-induced putative kinase 1, Pink1-PA, Pink1-PB, Pink1-PC, Pink1-PD, Pink1-PE, Pink1-PF, Pink1-PG, Pink1-PH, isoform C, PTEN-induced putative kinase 1 |
| Other gene names: |
BEST:GH23468, CG4523, DmelCG4523, N/A, N/A, PINK, PINK1, dPINK1, dPink1, pink1, Pink1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Source: Mouse, Host: Rabbit |
| Species reactivity: |
Mouse, Human |
| Specificity and cross-reactivity: |
Species Crossreactivity: Human and mouse, Recognizes PTEN-induced kinase |
| Purification method: |
Affinity Purified by immunoaffinity chromatography |
| Form/Appearance: |
Supplied as a liquid |
| Storage and shipping: |
Aliquots are stable for at least 12 months productone should be stored at -20 degrees Celsius, For long-term storage and to avoid repeated freezing and thawing, For maximum recovery of product, For optimal long term storage, Further dilutions can be made in assay buffe, aliquot and add glycerol (40-50%), centrifuge the original vial after thawing and prior to removing the cap, productone should be kept at -20 degrees Celsius, Store at 4 degrees Celsius for short term storage |
| Tested for:: |
Immunohistochemistry (IHC), Western Blot (WB) |
| Description: |
factors or kinases, increase , (an , Induced protein genes, at , enzyme , genetic transcription, level , of , of , or , other , production , protein) , the , the |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
PTEN Kinase (PINK1) |
| Short name: |
PTEN- Kinase (PINK1) |
| Alternative name: |
phosphatase and tensin homolog-Induced phosphorylation catalyst (phosphatase and tensin homolog induced putative kinase 1) |
| Alternative to gene target: |
10q23del and BZS and CWS1 and DEC and GLM2 and MHAM and MMAC1 and PTEN1 and TEP1, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, PTEN and IDBG-637256 and ENSBTAG00000009498 and 540786, PTEN and IDBG-81409 and ENSG00000171862 and 5728, PTEN induced putative kinase 1, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, Pten and IDBG-158878 and ENSMUSG00000013663 and 19211, dopaminergic and biological process this GO :0033603 and positive regulation of dopamine secretion and biological process this GO :0033605 and positive regulation of catecholamine secretion and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043254 and regulation of protein complex assembly and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0055131 and C3HC4-type RING finger domain binding and molecular function this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097237 and cellular response to toxic substance and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process, nuclei, nuclei, phosphatidylinositol-3, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000287 and magnesium ion binding and molecular function this GO :0001525 and angiogenesis and biological process this GO :0001933 and negative regulation of protein phosphorylation and biological process this GO :0002902 and regulation of B cell apoptotic process and biological process this GO :0004438 and phosphatidylinositol-3-phosphatase activity and molecular function this GO :0004721 and phosphoprotein phosphatase activity and molecular function this GO :0004722 and protein serine/threonine phosphatase activity and molecular function this GO :0004725 and protein tyrosine phosphatase activity and molecular function this GO :0005161 and platelet-derived growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006470 and protein dephosphorylation and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007092 and activation of mitotic anaphase-promoting complex activity and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007270 and neuron-neuron synaptic transmission and biological process this GO :0007416 and synapse assembly and biological process this GO :0007417 and central nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0007611 and learning or memory and biological process this GO :0007613 and memory and biological process this GO :0007626 and locomotory behavior and biological process this GO :0008138 and protein tyrosine/serine/threonine phosphatase activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009749 and response to glucose and biological process this GO :0009898 and cytoplasmic side of plasma membrane and cellular component this GO :0010033 and response to organic substance and biological process this GO :0010035 and response to inorganic substance and biological process this GO :0010043 and response to zinc ion and biological process this GO :0010975 and regulation of neuron projection development and biological process this GO :0010997 and anaphase-promoting complex binding and molecular function this GO :0014067 and negative regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016311 and dephosphorylation and biological process this GO :0016314 and phosphatidylinositol-3, this GO :0000287 and magnesium ion binding and molecular function this GO :0000422 and mitochondrion degradation and biological process this GO :0000785 and chromatin and cellular component this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005743 and mitochondrial inner membrane and cellular component this GO :0005758 and mitochondrial intermembrane space and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006950 and response to stress and biological process this GO :0008219 and cell death and biological process this GO :0010857 and calcium-dependent protein kinase activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016567 and protein ubiquitination and biological process this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0004438 : phosphatidylinositol-3-phosphatase activity and also this GO :0004721 : phosphoprotein phosphatase activity and also this GO :0004722 : protein serine/threonine phosphatase activity and also this GO :0004725 : protein tyrosine phosphatase activity and also this GO :0005161 : platelet-derived growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity and also this GO :0008289 : lipid binding and also this GO :0010997 : anaphase-promoting complex binding and also this GO :0016314 : phosphatidylinositol-3, this GO :0000287 : magnesium ion binding and also this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0010857 : calcium-dependent protein kinase activity and also this GO :0016301 : kinase activity and also this GO :0016772 : transferase activity, this GO :0004438 : phosphatidylinositol-3-phosphatase activity, this GO :0004672 : protein kinase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004721 : phosphoprotein phosphatase activity, this GO :0004722 : protein serine/threonine phosphatase activity, this GO :0004725 : protein tyrosine phosphatase activity, this GO :0005161 : platelet-derived growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008138 : protein tyrosine/serine/threonine phosphatase activity, this GO :0008289 : lipid binding, this GO :0010857 : calcium-dependent protein kinase activity, this GO :0010997 : anaphase-promoting complex binding, this GO :0016301 : kinase activity, this GO :0016314 : phosphatidylinositol-3, this GO :0016772 : transferase activity, this GO :0016791 : phosphatase activity, this GO :0019899 : enzyme binding, this GO :0019901 : protein kinase binding, this GO :0030165 : PDZ domain binding, this GO :0031625 : ubiquitin protein ligase binding, this GO :0051717 : inositol-1, this GO :0051800 : phosphatidylinositol-3, this GO :0055131 : C3HC4-type RING finger domain binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0055131 : C3HC4-type RING finger domain binding, transferring phosphorus-containing groups and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0031396 and regulation of protein ubiquitination and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032226 and positive regulation of synaptic transmission, 3, 3, 3, 4, 4, 4, 4, 4, 4, 4-bisphosphate 3-phosphatase activity, 4-bisphosphate 3-phosphatase activity, 4-bisphosphate 3-phosphatase activity and molecular function this GO :0051895 and negative regulation of focal adhesion assembly and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0060024 and rhythmic synaptic transmission and biological process this GO :0060070 and canonical Wnt signaling pathway and biological process this GO :0060074 and synapse maturation and biological process this GO :0060134 and prepulse inhibition and biological process this GO :0060179 and male mating behavior and biological process this GO :0060291 and long-term synaptic potentiation and biological process this GO :0060292 and long term synaptic depression and biological process this GO :0060736 and prostate gland growth and biological process this GO :0060997 and dendritic spine morphogenesis and biological process this GO :0061002 and negative regulation of dendritic spine morphogenesis and biological process this GO :0090071 and negative regulation of ribosome biogenesis and biological process this GO :0090344 and negative regulation of cell aging and biological process this GO :0090394 and negative regulation of excitatory postsynaptic membrane potential and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097107 and postsynaptic density assembly and biological process this GO :2000060 and positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :2000134 and negative regulation of G1/S transition of mitotic cell cycle and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process this GO :2000808 and negative regulation of synaptic vesicle clustering and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, 5-tetrakisphosphate 3-phosphatase activity, 5-tetrakisphosphate 3-phosphatase activity and also this GO :0051800 : phosphatidylinositol-3, 5-tetrakisphosphate 3-phosphatase activity and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0051800 and phosphatidylinositol-3, 5-trisphosphate 3-phosphatase activity, 5-trisphosphate 3-phosphatase activity and also this GO :0016791 : phosphatase activity and also this GO :0019899 : enzyme binding and also this GO :0019901 : protein kinase binding and also this GO :0030165 : PDZ domain binding and also this GO :0051717 : inositol-1, 5-trisphosphate 3-phosphatase activity and molecular function this GO :0016477 and cell migration and biological process this GO :0016605 and PML body and cellular component this GO :0016791 and phosphatase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0021542 and dentate gyrus development and biological process this GO :0021955 and central nervous system neuron axonogenesis and biological process this GO :0030165 and PDZ domain binding and molecular function this GO :0030336 and negative regulation of cell migration and biological process this GO :0031175 and neuron projection development and biological process this GO :0031642 and negative regulation of myelination and biological process this GO :0031647 and regulation of protein stability and biological process this GO :0031658 and negative regulation of cyclin-dependent protein kinase activity involved in G1/S and biological process this GO :0032286 and central nervous system myelin maintenance and biological process this GO :0032355 and response to estradiol and biological process this GO :0032535 and regulation of cellular component size and biological process this GO :0033032 and regulation of myeloid cell apoptotic process and biological process this GO :0033198 and response to ATP and biological process this GO :0033555 and multicellular organismal response to stress and biological process this GO :0035176 and social behavior and biological process this GO :0035335 and peptidyl-tyrosine dephosphorylation and biological process this GO :0035749 and myelin sheath adaxonal region and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042493 and response to drug and biological process this GO :0042711 and maternal behavior and biological process this GO :0042995 and cell projection and cellular component this GO :0043005 and neuron projection and cellular component this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043197 and dendritic spine and cellular component this GO :0043220 and Schmidt-Lanterman incisure and cellular component this GO :0043491 and protein kinase B signaling and biological process this GO :0043542 and endothelial cell migration and biological process this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045211 and postsynaptic membrane and cellular component this GO :0045471 and response to ethanol and biological process this GO :0045475 and locomotor rhythm and biological process this GO :0045792 and negative regulation of cell size and biological process this GO :0046621 and negative regulation of organ growth and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046855 and inositol phosphate dephosphorylation and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048738 and cardiac muscle tissue development and biological process this GO :0048853 and forebrain morphogenesis and biological process this GO :0048854 and brain morphogenesis and biological process this GO :0050680 and negative regulation of epithelial cell proliferation and biological process this GO :0050765 and negative regulation of pha this GO cytosis and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0050821 and protein stabilization and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051717 and inositol-1, phosphatase and tensin homolog |
| Identity: |
14581 |
| Gene: |
PINK1 |
More about : PINK1 |
| Long gene name: |
PTEN induced putative kinase 1 |
| Synonyms gene: |
PARK6 |
| Synonyms gene name: |
Parkinson disease (autosomal recessive) 6 |
| Locus: |
1p36, 12 |
| Discovery year: |
2001-02-08 |
| GenBank acession: |
AB053323 |
| Entrez gene record: |
65018 |
| Pubmed identfication: |
11494141 15349860 |
| RefSeq identity: |
NM_032409 |
| Classification: |
Parkinson disease associated genes |
| Havana BLAST/BLAT: |
OTTHUMG00000002841 |
| Locus Specific Databases: |
Parkinson', s disease Mutation Database |