| Also known as: |
Platelet gpIIb IIIa, CD41 |
| Other names: |
N/A, CD41 antigen |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
22, SZ |
| Host organism: |
Hybridization of X63-Ag14 myeloma cells with spleen cells from BALB/c mice, Source: Ascites, Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD41 is the integrin alpha IIb chain, Does not inhibit the fibrinogen binding to human platelets induced by ADP, Does not inhibit the platelet aggregation and secretion induced by collagen, It reacts specifically with normal platelets and megakaryocytes but studeis have shown that it does not react with Glanzamann's thrombasthenic platelets which lack the membrane glycoprotein gpIIbIIIa, Platelet gpIIb IIIa The molecular weight of the recognized antigen is 135kDa, Reacts with the alpha chain of gpIIb independently of the presence of gpIIIa, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, also called gpIIIa (CD61), also called gpIIb, arachidonic acid and PAF, arachidonic acid and thrombin, forming the gpIIbIIIa complex, which is non-covalently associated with the integrin beta 3 chain, CD41 |
| Purification method: |
Protein A chromatography |
| Form/Appearance: |
Lyophilized Reconstitute with 1ml distilled water, Purified |
| Concentration: |
2mg/ml (prior to lyophilization) |
| Storage and shipping: |
After reconstitution, Avoid multiple freeze/thaw cycles, The addition of 0, aliquot and For optimal long term storage, the antibody should be kept at -20 degrees Celsius, 1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to 1 month at 2 to 8 degree C, Store lyophilized product at 2 to 8 degree C |
| Tested applications:: |
Western Blot, Flow Cytometry |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
MAb CD41 gpIIb IIIa |
| Short name: |
MAb CD41 gpIIb IIIa Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
monoclonal to CD41 gpIIb IIIa (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6138 |
| Gene: |
ITGA2B |
More about : ITGA2B |
| Long gene name: |
integrin subunit alpha 2b |
| Synonyms gene: |
GP2B |
| Synonyms gene name: |
alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) , antigen CD41B) integrin, integrin |
| Synonyms: |
CD41B CD41 PPP1R93 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 93 platelet glycoprotein IIb of IIb/IIIa complex |
| Locus: |
17q21, 31 |
| Discovery year: |
1986-01-01 |
| Entrez gene record: |
3674 |
| Classification: |
Integrin alpha subunits CD molecules Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000177935 |
| Locus Specific Databases: |
LRG_479 |