| Long name: |
277, 79) Monoclonal Antibody, FLT1 (1453CT519 |
| Also known as: |
277, 79) Monoclonal Antibody, FLT1 (1453CT519 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FLT1 |
| Specificity: |
This is a highly specific antibody against FLT1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1453CT519, 79, 277 |
| Source: |
This FLT1 antibody is generated from a mouse immunized with a recombinant protein |
| Gene ID number: |
2321 |
| Swiss Prot: |
P17948 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, Can promote endothelial cell proliferation, Has very high affinity for VEGFA and relatively low protein kinase activity, Isoform 1 phosphorylates PLCG, Its function in promoting cell proliferation seems to be cell-type specific, Ligand binding leads to the activation of several signaling cascades, Likewise, MAPK3/ERK1 and the MAP kinase signaling pathway, May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells, Mediates activation of MAPK1/ERK2, Mediates phosphorylation of PIK3R1, Modulates KDR signaling by forming heterodimers with KDR, Phosphorylates SRC and YES1, Promotes PGF-mediated proliferation of endothelial cells, Promotes phosphorylation of AKT1 at 'Ser-473', VEGFB and PGF, and cancer cell invasion, and may also phosphorylate CBL, and plays an essential role in the development of embryonic vasculature, as well as of the AKT1 signaling pathway, but does not promote proliferation of normal fibroblasts (in vitro), cell migration, cell survival, chemotaxis, isoform 3 and isoform 4, isoforms lacking a transmembrane domain, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway, macrophage function, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR, may function as decoy receptors for VEGFA, proliferation of some types of cancer cells, such as isoform 2, survival and angiogenesis in adulthood, the regulation of angiogenesis, the regulatory subunit of phosphatidylinositol 3-kinase, 4, 5-trisphosphate and the activation of protein kinase C, Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA |
| Purification method: |
This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FLT-1, FLT1, FRT, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, VEGFR-1, VEGFR1, Vascular endothelial growth factor receptor 1, Vascular permeability factor receptor, FLT |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
277, 79) Monoclonal, FLT1 (1453CT519 |
| Short name: |
277, 79) Monoclonal Antibody, FLT1 (1453CT519 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
277, 79) monoclonal (Antibody to), FLT1 (1453CT519 |
| Alternative technique: |
antibodies |
| Identity: |
3763 |
| Gene: |
FLT1 |
More about : FLT1 |
| Long gene name: |
fms related tyrosine kinase 1 |
| Synonyms gene: |
FLT |
| Synonyms gene name: |
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) fms-related tyrosine kinase 1 |
| Synonyms: |
VEGFR1 |
| Synonyms name: |
vascular endothelial growth factor receptor 1 vascular permeability factor receptor |
| Locus: |
13q12, 3 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF063657 |
| Entrez gene record: |
2321 |
| Pubmed identfication: |
2158038 |
| RefSeq identity: |
NM_002019 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016648 |
| Locus Specific Databases: |
The Globin Gene Server LRG_425 |