| Long name: |
12, 17) Monoclonal Antibody, FER (1457CT181 |
| Also known as: |
12, 17) Monoclonal Antibody, FER (1457CT181 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FER |
| Specificity: |
This is a highly specific antibody against FER |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
12, 1457CT181, 17 |
| Source: |
This FER antibody is generated from a mouse immunized with a recombinant protein |
| Gene ID number: |
2241 |
| Swiss Prot: |
P16591 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000), IHC(1:25) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts downstream of EGFR, Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation, Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells, CTNND1, Can phosphorylate STAT3, GAB1, KIT, May phosphorylate JUP and PTPN1, May play a role in the regulation of the mitotic cell cycle, PDGFRA and PDGFRB, PECAM1 and PTPN11, PTK2/FAK1, Phosphorylates CTTN, Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS), Plays a role in neuronal cell death after brain damage, Plays a role in synapse organization, Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase, Plays a role in the regulation of mast cell degranulation, but the biological relevance of this depends on cell type and stimulus, cell adhesion, cell migration and chemotaxis, lamellipodia formation, microtubule assembly, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission, trafficking of synaptic vesicles, Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton |
| Purification method: |
This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FER, Feline encephalitis virus-related kinase FER, Fujinami poultry sarcoma/Feline sarcoma-related protein Fer, PPP1R74, Proto-oncogene c-Fer, Tyrosine kinase 3, Tyrosine-protein kinase Fer, p94-Fer, TYK3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
12, 17) Monoclonal, FER (1457CT181 |
| Short name: |
12, 17) Monoclonal Antibody, FER (1457CT181 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
12, 17) monoclonal (Antibody to), fer (fps/fes related) tyrosine kinase (1457CT181 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FER and IDBG-36195 and ENSG00000151422 and 2241, FER and IDBG-646625 and ENSBTAG00000003051 and 536759, Fer and IDBG-194638 and ENSMUSG00000000127 and 14158, FerT and Pe1Fe10 and Pe1Fe13 and Pe1Fe3 and Pe1Fe6 and PPP1R74 and TYK3, nuclei, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0003779 and actin binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006935 and chemotaxis and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0008157 and protein phosphatase 1 binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0010591 and regulation of lamellipodium assembly and biological process this GO :0010762 and regulation of fibroblast migration and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0015630 and microtubule cytoskeleton and cellular component this GO :0016772 and transferase activity, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008092 : cytoskeletal protein binding and also this GO :0008157 : protein phosphatase 1 binding and also this GO :0008289 : lipid binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008092 : cytoskeletal protein binding, this GO :0008157 : protein phosphatase 1 binding, this GO :0008289 : lipid binding, this GO :0016772 : transferase activity, this GO :0017137 : Rab GTPase binding, this GO :0019901 : protein kinase binding, this GO :0045295 : gamma-catenin binding, this GO :0045296 : cadherin binding, this GO :0050839 : cell adhesion molecule binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0017137 : Rab GTPase binding and also this GO :0019901 : protein kinase binding and also this GO :0045295 : gamma-catenin binding and also this GO :0045296 : cadherin binding and also this GO :0050839 : cell adhesion molecule binding, transferring phosphorus-containing groups and molecular function this GO :0017137 and Rab GTPase binding and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030054 and cell junction and cellular component this GO :0030335 and positive regulation of cell migration and biological process this GO :0030838 and positive regulation of actin filament polymerization and biological process this GO :0031234 and extrinsic component of cytoplasmic side of plasma membrane and cellular component this GO :0031532 and actin cytoskeleton reorganization and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0033007 and negative regulation of mast cell activation involved in immune response and biological process this GO :0034446 and substrate adhesion-dependent cell spreading and biological process this GO :0034614 and cellular response to reactive oxygen species and biological process this GO :0035426 and extracellular matrix-cell signaling and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0036006 and cellular response to macrophage colony-stimulating factor stimulus and biological process this GO :0036119 and response to platelet-derived growth factor stimulus and biological process this GO :0038028 and insulin receptor signaling pathway via phosphatidylinositol 3-kinase and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038109 and Kit signaling pathway and biological process this GO :0042058 and regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0042503 and tyrosine phosphorylation of Stat3 protein and biological process this GO :0044331 and cell-cell adhesion mediated by cadherin and biological process this GO :0045295 and gamma-catenin binding and molecular function this GO :0045296 and cadherin binding and molecular function this GO :0046777 and protein autophosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050904 and diapedesis and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0070102 and interleukin-6-mediated signaling pathway and biological process, fer (fps/fes related) tyrosine kinase |
| Identity: |
3655 |
| Gene: |
FER |
More about : FER |
| Long gene name: |
FER tyrosine kinase |
| Synonyms gene name: |
fer (fps/fes related) tyrosine kinase |
| Synonyms: |
TYK3 PPP1R74 |
| Synonyms name: |
phosphoprotein NCP94 protein phosphatase 1, regulatory subunit 74 |
| Locus: |
5q21, 3 |
| Discovery year: |
1990-03-05 |
| GenBank acession: |
J03358 |
| Entrez gene record: |
2241 |
| Pubmed identfication: |
2725517 |
| RefSeq identity: |
NM_005246 |
| Classification: |
SH2 domain containing Protein phosphatase 1 regulatory subunits F-BAR domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000128751 |